Heart Failure in Adult Patients With a History of Congenital Heart Disease - Full Text View

Sponsored by:	Emory University
Information provided by:	Emory University
ClinicalTrials.gov Identifier:	NCT00208754

Purpose

In today's world of advanced surgery, children born with congenital heart disease (CHD) are surviving into adulthood. However, the surgical procedures these children undergo do not cure the underlying problem and this these children develop other heart problems later in life. Heart failure is the one of the most common heart problems effecting these patients. This heart failure can be seen in both lower pumping chambers of the heart, however, sometimes only one side of the heart is affected. Since there are several congenital heart defects that are now seen in the adult population, an understanding of what causes heart failure in this patient population can help physicians develop better treatments for this condition. The goal of this study is to review the medical records of 350 adult patients with congenital heart disease that has developed heart failure. During this review, we plan to collect information regarding the various treatments utilized in these patients and to determine if there are any common elements regarding the development of heart failure in adult patients with CHD.

Condition
Congenital Heart Defects

MedlinePlus related topics: Congenital Heart Defects Heart Diseases Heart Failure

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Retrospective Study
Official Title:	Heart Failure in Adult Patients With a History of Congenital Heart Disease.

Further study details as provided by Emory University:

Estimated Enrollment:	350
Study Start Date:	May 2004
Estimated Study Completion Date:	December 2005

Detailed Description:

In today's world of advanced surgery, children born with congenital heart disease (CHD) are surviving into adulthood. However, the surgical procedures these children undergo do not cure the underlying problem and this these children develop other heart problems later in life. Heart failure is the one of the most common heart problems effecting these patients. This heart failure can be seen in both lower pumping chambers of the heart, however, sometimes only one side of the heart is affected. Since there are several congenital heart defects that are now seen in the adult population, an understanding of what causes heart failure in this patient population can help physicians develop better treatments for this condition. The goal of this study is to review the medical records of 350 adult patients with congenital heart disease that has developed heart failure. During this review, we plan to collect information regarding the various treatments utilized in these patients and to determine if there are any common elements regarding the development of heart failure in adult patients with CHD.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Adults who have a history of congenital heart defects

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00208754

Locations

United States, Georgia
Emory University Hospital
Atlanta, Georgia, United States, 30322

Sponsors and Collaborators

Emory University

Investigators

Principal Investigator:

Wendy Book, MD

Emory University

More Information

Publications:

Bolger AP, Coats AJ, Gatzoulis MA. Congenital heart disease: the original heart failure syndrome. Eur Heart J. 2003 May;24(10):970-6. Review.

Jessup M, Brozena S. Heart failure. N Engl J Med. 2003 May 15;348(20):2007-18. Review. No abstract available.

Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, DiBianco R, Zeldis SM, Hendrix GH, Bommer WJ, Elkayam U, Kukin ML, et al. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med. 1991 Nov 21;325(21):1468-75.

Deshpande RB, Deodhar LP. Ocular and orbital tumours and tumour-like lesions: a clinico-pathological study of 64 cases. J Postgrad Med. 1977 Apr;23(2):84-8. No abstract available.

Study ID Numbers:	489-2004
Study First Received:	September 13, 2005
Last Updated:	October 31, 2006
ClinicalTrials.gov Identifier:	NCT00208754
Health Authority:	United States: Food and Drug Administration

Keywords provided by Emory University:

heart defects
cardiology
adults who have congenital heart defects

Study placed in the following topic categories:

Heart Failure
Heart Diseases
Cardiovascular Abnormalities
Congenital Abnormalities
Heart Defects, Congenital

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009