Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
University of Zurich |
---|---|
Information provided by: | University of Zurich |
ClinicalTrials.gov Identifier: | NCT00521573 |
The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
Condition | Intervention | Phase |
---|---|---|
Heart Transplantation |
Other: Dark chocolate |
Phase I |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Parallel Assignment |
Dark chocolate contains a high amount of flavonoids. Flavonoids hold the possibilities to improve oxidative stress and hence the possibility to improve endothelium-dependent coronary vasomotion, which is a powerful surrogate for clinical prognosis. Coronary atherosclerosis is promoted by impaired endothelial function and increased platelet activation. High oxidative stress and reduced antioxidant defenses play a crucial role in the pathogenesis of atherosclerosis, in particular in transplanted hearts. The aim of the present study is to investigate whether the ingestion of a flavonoid-rich dark chocolate compared to flavonoid-free placebo chocolate will improve coronary vasomotion in heart transplanted patients.
Ages Eligible for Study: | 20 Years to 80 Years |
Genders Eligible for Study: | Both |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | EK1129 |
Study First Received: | August 27, 2007 |
Last Updated: | August 27, 2007 |
ClinicalTrials.gov Identifier: | NCT00521573 |
Health Authority: | Switzerland: Swissmedic |