How Does Your Genetic Make-up (Profile) Influence Your Glaucoma? - Full Text View

Sponsored by:	Wills Eye
Information provided by:	Wills Eye
ClinicalTrials.gov Identifier:	NCT00626847

Purpose

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.

Condition	Intervention
Primary Open Angle Glaucoma Primary Angle Closure Glaucoma Pseudoexfoliation Glaucoma	Genetic: Nuclear Genetic and Mitochondrial DNA

Genetics Home Reference related topics: early-onset glaucoma

MedlinePlus related topics: Glaucoma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Nuclear Genetic and Mitochondrial Influences in Glaucoma

Further study details as provided by Wills Eye:

Primary Outcome Measures:

The investigators will sequence the entire mitochondrial genome to determine mitochondrial DNA nucleotide changes associated with different types of glaucoma in ethnic Americans. [ Time Frame: unknown ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: unknown ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples With DNA

Biospecimen Description:

whole blood

Estimated Enrollment:	600
Study Start Date:	March 2008
Estimated Study Completion Date:	December 2009
Estimated Primary Completion Date:	October 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
1 Primary Open Angle Glaucoma (POAG)	Genetic: Nuclear Genetic and Mitochondrial DNA Mapping of your genetic make-up
2 Primary Angle Closure Glaucoma (PACG)	Genetic: Nuclear Genetic and Mitochondrial DNA Mapping of your genetic make-up
3 Pseudoexfoliation Glaucoma	Genetic: Nuclear Genetic and Mitochondrial DNA Mapping of your genetic make-up
4 Controls (Normals)	Genetic: Nuclear Genetic and Mitochondrial DNA Mapping of your genetic make-up

Detailed Description:

Four tubes of blood will be taken from 600 people. Of those, half will have glaucoma and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. Three groups will consist of POAG, PACG, and Pseudoexfoliation glaucoma. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

Eligibility

Ages Eligible for Study:	40 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

glaucoma clinic

Criteria

Inclusion Criteria:

40 yrs
Caucasian or African American
Male or female with POAG, PACG, PXFG,
Normal

Exclusion Criteria:

Other ophthamic co-morbidities
Other ethnic groups
Unable to understand and give informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00626847

Contacts

Contact: George L Spaeth, MD	215-928-3197	gspaeth@willseye.org
Contact: Jeanne L Molineaux, COA	215-825-4713	jmolineaux@willseye.org

Locations

United States, Pennsylvania
Wills Eye Glaucoma Service	Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Mary Jo Schwartz 215-928-3123 mschwartz@willseye.org
Contact: Sheryl S Wizov, COA 215-928-3221 swizov@willseye.org
Sub-Investigator: Jonathan S Myers, MD
Sub-Investigator: Jay L Katz, MD
Sub-Investigator: Marlene R Moster, MD
Sub-Investigator: Michael J Pro, MD
Sub-Investigator: Courtland M Schmidt, MD
Sub-Investigator: Scott Fudemberg, MD
Sub-Investigator: Arun Prasad, MD
Sub-Investigator: Anand Montravadi, MD

Sponsors and Collaborators

Wills Eye

Investigators

Principal Investigator:

George L Spaeth, MD

Wills Eye Institute

More Information

Responsible Party:	Wills Eye Institute ( George L. Spaeth, MD )
Study ID Numbers:	IRB#07-826
Study First Received:	February 20, 2008
Last Updated:	November 12, 2008
ClinicalTrials.gov Identifier:	NCT00626847
Health Authority:	United States: Institutional Review Board

Keywords provided by Wills Eye:

primary open angle glaucoma
primary angle closure glaucoma
pseudoexfoliation glaucoma
Nuclear Genetics

Mitochondrial DNA
POAG
PACG
PXFG

Study placed in the following topic categories:

Glaucoma
Eye Diseases
Glaucoma, Open-Angle
Exfoliation Syndrome

Glaucoma, Angle-Closure
Hypertension
Ocular Hypertension

Additional relevant MeSH terms:

Uveal Diseases
Iris Diseases

ClinicalTrials.gov processed this record on January 16, 2009