Inclusion Criteria:

• Male or female >= 18 years of age
• Diagnosis of ulcerative colitis for greater than 90 days prior to Baseline
• Diagnosis of active ulcerative colitis confirmed by colonoscopy with biopsy or flexible sigmoidoscopy with biopsy during the Screening Period, with exclusion of infection
• Subject is judged to be in generally good health as determined by the principal investigator

Exclusion Criteria:

• History of subtotal colectomy with ileorectostomy or colectomy with ileoanal pouch, Koch pouch, or ileostomy for ulcerative colitis or is planning bowel surgery
• Received infliximab or any other anti-TNF agent in the past
• Current diagnosis of fulminant colitis and/or toxic megacolon
• Subjects with disease limited to the rectum (ulcerative proctitis)
• Current diagnosis of indeterminate colitis
• Current diagnosis and/or history of Crohn's disease
• Persistent chronic or active non-UC related infections requiring treatment with intravenous (iv) antibiotics, iv antivirals, or iv antifungals within 30 days prior to Baseline or oral antibiotics, oral antivirals, or oral antifungals within 14 days prior to Baseline
• History of malignancy other than a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma and/or localized carcinoma in situ of the cervix.
• If the Screening colonoscopy/flexible sigmoidoscopy shows evidence of dysplasia or a malignancy, subject may not be enrolled in the study
• Subject considered by the investigator, for any reason, to be an unsuitable candidate
• Female subject who is pregnant or breast-feeding or considering becoming pregnant