Inclusion Criteria:

• A male or non-pregnant female 18 to 50 years of age (inclusive) at the time of screening
• Written informed consent obtained from the participant before screening procedures
• Free of clinically significant health problems as established by medical history and clinical examination before entering into the study*
• Available to participate for duration of study (approximately five months, not including screening)
• If the participant is female, she must be of non-childbearing potential, i.e., either surgically sterilized or one year post-menopausal; or, if of childbearing potential, she must be abstinent or have used adequate contraceptive precautions (e.g., intrauterine contraceptive device; oral contraceptives; diaphragm or condom in combination with contraceptive jelly, cream or foam; Norplant® or Depo-Provera®) during this study, have a negative pregnancy test at the time of each immunization, and must agree to continue such precautions for two months after completion of the immunization series and the malaria challenge.
• Prior to entry into this study, participants must score at least 80% correct on a short multiple-choice quiz that assesses their understanding of this study. If they do not score 80% on the initial quiz, the protocol information will be reviewed with them to ensure comprehension and they will have the opportunity to retest. Participants who fail the Comprehension Assessment for the second time will not be enrolled.

Exclusion Criteria:

• Prior receipt of an investigational malaria vaccine
• Use of any investigational or non-registered drug or vaccine other than the study vaccine(s) within 30 days preceding the first study immunization or planned use during the study period, or receipt of investigational vaccine containing 3-D MPL and/or QS-21 at any time in the past (Have you received an experimental vaccine with a GSK adjuvant in the past?)
• Administration of chronic (defined as more than 14 days) immunosuppressants or other immune-modifying drugs within six months of immunization. (For corticosteroids, this will mean prednisone, or equivalent, greater than or equal to 0.5 mg/kg/day. Inhaled and topical steroids are allowed.)
• Chronic use of antibiotics with anti-malarial effects (e.g., tetracyclines for dermatologic patients, sulfa for recurrent urinary tract infections, etc.)
• Planned administration of a vaccine not foreseen by the study protocol 30 days prior to or after the first immunization
• History of malaria chemoprophylaxis within 60 days prior to immunization
• Any history of malaria
• Known exposure to malaria within the previous 12 months
• Planned travel to malarious areas during the study period
• Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection
• History of allergic disease or reactions to any vaccine
• Chronic or active neurologic disorders including seizures, excluding a single febrile seizure as a child
• History of splenectomy
• Acute disease at the time of enrollment (Acute disease is defined as the presence of a moderate or severe illness with or without fever. All vaccines can be administered to persons with a minor illness such as diarrhea, mild upper respiratory infection with or without low-grade febrile illness, i.e., oral temperature < 37.5°C/99.5°F).
• Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests
• Personal medical histories including the following diagnoses: systemic lupus erythematosus, rheumatoid arthritis, mixed connective tissue disease, scleroderma, vasculitis, and multiple sclerosis
• Seropositive for hepatitis B surface antigen or hepatitis C antibody
• Hepatomegaly, right upper quadrant abdominal pain or tenderness
• Elevated serum creatinine, defined in this study as greater than or equal to 1.7 mg/dL in males and 1.4 mg/dL in females
• Significant unexplained anemia: hematocrit < 35%
• Administration of immunoglobulins and/or any blood products within the three months preceding the first study immunization or planned administration during the study period
• Pregnant or lactating female or female who intends to become pregnant during the study
• Suspected or known current alcohol abuse as defined by the American Psychiatric Association in DSM IV (Diagnostic and Statistical Manual of Mental Disorders- 4th edition)
• Chronic or active illicit and/or intravenous drug use
• History of severe anaphylactic reactions to mosquito bites
• History of psoriasis (given its interaction with chloroquine)
• Any history of anaphylaxis in reaction to immunization
• History of allergy to nickel, imidazole or tetracycline group of antibiotics
• History of sickle cell disease or sickle cell trait
• Any other significant finding that in the opinion of the investigator would increase the risk of having an adverse outcome from participating in this study