Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
University College London Hospitals |
---|---|
Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00033488 |
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for ovarian cancer.
PURPOSE: Screening trial to determine the best procedure to detect ovarian cancer in women who have a high genetic risk for developing ovarian cancer.
Condition | Intervention |
---|---|
Ovarian Cancer |
Procedure: annual screening Procedure: comparison of screening methods Procedure: cytology specimen collection procedure |
Study Type: | Interventional |
Study Design: | Screening |
Official Title: | The UK Familial Ovarian Cancer Screening Study |
Estimated Enrollment: | 5000 |
Study Start Date: | September 2000 |
OBJECTIVES:
OUTLINE: Patients undergo transvaginal ultrasonography of the ovaries (scheduled for the early follicular phase, day 3-6 of the menstrual cycle) and CA 125 measurement annually. Blood samples are collected every 4 months for analysis of CA 125 levels and novel markers.
Peer Reviewed and Funded or Endorsed by Cancer Research UK
PROJECTED ACCRUAL: A total of 5,000 patients will be accrued for this study.
Ages Eligible for Study: | 35 Years and older |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
First-degree relative (mother, sister, or daughter) of an affected member of a high-risk family defined as one of the following:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Other:
United Kingdom, England | |
Institute of Child Health | Recruiting |
London, England, United Kingdom, WC1N 1EH | |
Contact: James Mackay, MD, MA, FRCP, FRCPE 44-20-7679-8099 j.mackay@ich.ucl.ac.uk | |
Saint Bartholomew's Hospital | Recruiting |
London, England, United Kingdom, EC1A 7BE | |
Contact: Ian Jacobs, MD 44-020-7601-8261 |
Study Chair: | James Mackay, MD, MA, FRCP, FRCPE | Institute of Child Health |
Study ID Numbers: | CDR0000069292, UKFOCSS, CRCA-FOCS, EU-20044 |
Study First Received: | April 9, 2002 |
Last Updated: | July 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00033488 |
Health Authority: | Unspecified |
ovarian epithelial cancer |
Genital Diseases, Female Ovarian cancer Ovarian Neoplasms Gonadal Disorders Genital Neoplasms, Female Endocrine System Diseases |
Urogenital Neoplasms Endocrinopathy Ovarian Diseases Ovarian epithelial cancer Endocrine Gland Neoplasms |
Neoplasms Neoplasms by Site Adnexal Diseases |