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Sponsors and Collaborators: |
London School of Hygiene and Tropical Medicine Medical Research Council National Malaria Control Programme, The Gambia |
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Information provided by: | London School of Hygiene and Tropical Medicine |
ClinicalTrials.gov Identifier: | NCT00118794 |
Lapdap (chlorproguanil-dapsone) is an affordable and effective drug, but patients with glucose-6-phosphate dehydrogenase (G6PD) A- deficiency are more susceptible to the haemolytic effects of the dapsone component of Lapdap; therefore there is a need to evaluate the extent to which the risks associated with the use of the drug in settings without G6PD screening might outweigh the benefits to malaria treatment. The investigators will evaluate, in operational settings, the safety and effectiveness of Lapdap and coartemether (lumefantrine-artemether) for treatment of uncomplicated malaria in patients 6 months to 10 years of age.
Condition | Intervention | Phase |
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Malaria |
Drug: Chlorproguanil-dapsone (Lapdap) Drug: Lumefantrine-artemether (Coartemether ) |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Randomized Trial of the Safety and Effectiveness of Lapdap and Coartemether for Uncomplicated Malaria in Operational Settings |
Estimated Enrollment: | 1200 |
Study Start Date: | September 2004 |
Estimated Study Completion Date: | June 2005 |
Patients with uncomplicated malaria will be recruited at three health centres in the Gambia. Children aged 6 months to 10 years presenting with a history of illness, who have a fever or recent history of fever, will be screened; those with uncomplicated malaria, a positive blood smear with a parasite density of 500 to 200,000 parasites/µl, monoinfection with P. falciparum, and a packed cell volume of >=20%, will be invited to enroll into the study and if consent is given, will be randomized to receive three daily doses of lapdap, or a six-dose course of Coartem. The first dose will be given by the mother under direct observation by the dispensing nurse; subsequent doses will be given at home unsupervised. Children will be followed up actively three times; on day 3, to assess adherence to the treatment regimen, and on days 14 and 28, to assess parasitological and haematological recovery. The mother/caregiver of the child will be encouraged to bring the child to the clinic if the child does not improve or if she is concerned about the child’s health. On day 3, the parent/caregiver will be visited at home (after the last dose should have been taken) in order to check for any leftover medication, and to ask about compliance and adverse reactions. A finger prick blood sample will be taken for Hb measurement by haemocue in the field and for a filter paper sample for measurement of drug concentration. The investigators will employ a longitudinal randomized design, whereby subsequent episodes of malaria will be treated according to the original randomization. This will enable better assessment of cumulative effects of repeated treatments on anaemia and on tolerability. Since patients with glucose-6-phosphate dehydrogenase (G6PD) A- deficiency are more susceptible to the haemolytic effects of the dapsone component of Lapdap, the investigators will determine the G6PD genotype and enzymatic activity, in order to evaluate the extent to which the risks associated with the use of the drug in settings without G6PD screening might outweigh the benefits to malaria treatment.
Ages Eligible for Study: | 6 Months to 10 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Gambia | |
Medical Research Council Laboratories | |
Banjul, Gambia, POBOX273 |
Principal Investigator: | Paul J Milligan, BSc MSc PhD | London School of Hygiene and Tropical Medicine |
Principal Investigator: | Sam K Dunyo, MD PhD | Medical Research Council |
Study ID Numbers: | SCC975, SCC975 |
Study First Received: | July 1, 2005 |
Last Updated: | January 31, 2006 |
ClinicalTrials.gov Identifier: | NCT00118794 |
Health Authority: | Gambia: Department of State for Health and Social Welfare |
uncomplicated malaria G6PD deficiency haemolytic anaemia Lapdap |
Artemsinin based combination treatment compliance pragmatic trials |
Benflumetol Glucose 6 phosphate dehydrogenase deficiency Protozoan Infections Von Gierke disease Anemia Dapsone |
Anemia, Hemolytic Parasitic Diseases Malaria Glycogen Storage Disease Type I Chlorproguanil Artemether |
Anti-Infective Agents Antimalarials Antiparasitic Agents Antiprotozoal Agents |
Coccidiosis Therapeutic Uses Pharmacologic Actions |