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Sponsored by: |
University of Chicago |
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Information provided by: | University of Chicago |
ClinicalTrials.gov Identifier: | NCT00607477 |
The purpose of this study is to describe the length of time and extent of blood pressure response to minoxidil and hydralazine among cancer patients with difficult-to-treat VEGF inhibitor treatment induced hypertension.
Condition | Intervention |
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Treatment Induced Hypertension |
Drug: Minoxidil Drug: Hydralazine |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | A Pilot Study of the Treatment of VEGF-Signaling Pathway Inhibitor-Induced Hypertension With Direct Vasodilators, Minoxidil and Hydralazine |
Estimated Enrollment: | 20 |
Study Start Date: | January 2008 |
Estimated Study Completion Date: | January 2009 |
Estimated Primary Completion Date: | January 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Active Comparator
Minoxidil
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Drug: Minoxidil
2.5mg taken twice daily for 1 week, followed by 5mg taken twice daily for the next week, followed by 10mg twice daily for the next week
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2: Active Comparator
Hydralazine
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Drug: Hydralazine
25mg taken twice daily for 1 week, followed by 50mg taken twice daily for the next week, followed by 100mg twice daily for the next week
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, Illinois | |
University of Chicago | Recruiting |
Chicago, Illinois, United States, 60637 | |
Contact: Rolanda Flynn 773-834-4059 rflynn@medicine.bsd.uchicago.edu | |
Principal Investigator: Michael Maitland, MD, PhD |
Principal Investigator: | Michael Maitland, M.D. | University of Chicago |
Responsible Party: | University of Chicago ( Michael Maitland, MD, PhD ) |
Study ID Numbers: | UCIRB 15386B |
Study First Received: | January 22, 2008 |
Last Updated: | August 4, 2008 |
ClinicalTrials.gov Identifier: | NCT00607477 |
Health Authority: | United States: Institutional Review Board |
Minoxidil Hydralazine Vascular Diseases Hypertension |
Vasodilator Agents Therapeutic Uses Cardiovascular Diseases |
Cardiovascular Agents Antihypertensive Agents Pharmacologic Actions |