I. Introduction
II. Bovine Corneal Opacity and Permeability (BCOP) Test Method
- BCOP Technical Summary
- ICCVAM Recommendations for the BCOP Test Method
III. Isolated Chicken Eye (ICE) Test Method
- ICE Technical Summary
- ICCVAM Recommendations for the ICE Test Method
IV. Isolated Rabbit Eye (IRE) Test Method
- IRE Technical Summary
- ICCVAM Recommendations for the IRE Test Method
V. Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) Test Method
- HET-CAM Technical Summary
- ICCVAM Recommendations for the HET-CAM Test Method
VI. Comparison of Performance Characteristics and
General Recommendations for Four Evaluated In Vitro Test Methods
VII. ICCVAM Recommendations on Substances for Validation of
In Vitro
Ocular Toxicity Test Methods for the Evaluation of Ocular Corrosives and Severe Irritants
VIII. References
APPENDICES
A: Expert Panel Reports
- Expert Panel Report: Evaluation of the Current Validation Status of
In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants
- Expert Panel Report: Evaluation of the Current Validation Status of
In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - Addendum
- Summary Minutes from Expert Panel Meeting on January 11-12, 2005
- Summary Minutes from Expert Panel Teleconference on September 19, 2005
B: Comparison of Performance Characteristics of Four In Vitro Test Methods
for the Identification of Severe Ocular Irritants or Corrosives
- Comparison of Performance Characteristics of Four In Vitro Test Methods for
Identification of GHS Severe Ocular Irritants or Corrosives
- Comparison of Performance Characteristics of Four In Vitro Test Methods for
Identification of EPA Severe Ocular Irritants or Corrosives
- Comparison of Performance Characteristics of Four In Vitro Test Methods for
Identification of EU Severe Ocular Irritants or Corrosives
C: Relevant Federal Ocular Irritation Regulations and Testing Guidelines
- Table of Relevant Ocular Irritation Regulations
- 16CFR1500.42: Test for Eye Irritants
- 29CFR1910.1200: Hazard Communication
- Health Effects Test Guidelines OPPTS 870.2400: Acute Eye Irritation
D: ICCVAM Recommended BCOP Test Method Protocol
E: ICCVAM Recommended ICE Test Method Protocol
F: ICCVAM Recommended IRE Test Method Protocol
G: ICCVAM Recommended HET-CAM Test Method Protocol
H: ICCVAM Recommended Reference Substances List
I: Federal Register Notices And Public Comments
- Federal Register Notices
- ICCVAM Consideration of Public Comments Received in Response to Federal Register Notices
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