Neurobiology and Pain Therapeutics, DIR
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 49 ROOM 1A07
49 CENTER DR
BETHESDA MD 20892
Phone: (301) 402-4981
Fax: (301) 402-0667
E-mail: hyang@dir.nidcr.nih.gov
Research Interests
Persistent nociceptive input is known to induce neuronal adaptation and synaptic plasticity in the spinal cord. To understand the molecular basis of these changes, the focus of my study has been on 1) searching for genes that are altered in the dorsal spinal cord during inflammatory hyperalgesia by subtraction hybridization and 2) regulation of the neuropeptide FF and NPFF receptor which are strikingly localized in the dorsal spinal cord to asses the role of the NPFF system during inflammatory hyperalgesia.
Education
B.S. (Agricultural Chemistry) National Tawian University 1950-54
M.S. (Biochemistry), Lousiana State University 1956-58
Ph.D. (Biochemistry), University of Oklahoma 1958-62
Recent publications
Yang HYT, Wilkening S and Iadarola MJ: Spinal cord genes enriched in dorsal horn and induced by noxious stimulation identified by subtraction cloning and differential hybridization. Neuroscience 103:493-502, 2001.
Yang HYT, Virata MLA, FitzGerald DJ, Iadarola MJ: Regulation of NPFF receptor mRNA and development of a NPFF receptor cytotoxic cojugate (NPFF-PE35). Society for Neuroscience 27, 2001.
Yang H-YT, Perez FM, Economou AP and Iadarola MJ: Tissue and cellular distributions and regulation of Arrestin E. Society for Neuroscience 26:1937, 2000.
Yang H-YT, Karoum F, Felder C, Badger H, Lin T-C and Markey SP: GC/MS analysis of anandamide (N-rachidonoylethanolamide) and quantification of N-arachidonoylphosphatidylethanolamides (N-ArPE), in various brain regions, spinal cord, testis and spleen of the rat. J of Neurochem, 72:1959-1968, 1999.
Goodman CB, Heyliger S, Emilien B, Partilla JS, Yang H-YT Lee CH, Cadet JL, Rothman RB: Chronic exposure to antibodies directed against anti-opiate peptides alter delta-opioid receptor levels. Peptides, 20:1419-24, 1999.
Yang HYT, Wilkening S, Iadarola MJ: Subtractive analysis of gene expression in rat dorsal spinal cord. Society for Neuroscience, 24:316, 1998.
Goodman CB, Heyliger S, Emilien B, Partilla JS, Yang H-YT, Lee C-H, Cadet JL, and Rothman, RB: Regulation of µ binding sites after chronic administration of antibodies directed against specific anti-opiate peptides. Peptides, 19:1703-1709, 1998.
Jhamandas JH, Harris KH, Petro T, Yang H-YT and Jhamandas KH: Activation of neuropeptide FF neurons in the brain stem nucleus tractus solitarius following cardiovascular challenge and opiate withdrawal. J of Comparative Neurology, 402:210-221, 1998.