Chief, Oral and Pharyngeal Cancer Branch, DIR
Chief, Cell Growth Regulation Section, and Molecular Carcinogenesis Unit, OPCB, DIR
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 211
30 CONVENT DR MSC 4340
BETHESDA MD 20892-4340
Phone: (301) 496-6259
Fax: (301) 402-0823
E-mail: Dr. J. Silvio Gutkind
Research Interests
Molecular basis of signal transduction in cell proliferation, differentiation and neoplastic transformation; the use of this knowledge to develop molecular markers of disease progression and novel therapeutic approaches for oral malignancies.
Education
1980 Pharmacy Degree (M.Sc.), University of Buenos Aires, Argentina
1983 Biochemistry Degree (M.Sc.), University of Buenos Aires, Argentina
1985 Ph.D. in Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Selected publications
Selected publications, signal transduction research:
Gutkind J.S., Novotny E., Brann M.R., and Robbins K.C. Muscarinic acetylcholine receptor subtypes as agonist dependent oncogenes. Proc. Natl. Acad. Sci. USA, 88:4703-4707, 1991.
Crespo P., Xu N., Simonds W.F., and Gutkind J.S. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature, 369:418-420, 1994.
Coso O., Chiariello M., Yu J.-C., Crespo P., Teramoto, H., Xu N., Miki T., and Gutkind J.S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK (SAPK) signaling pathway. Cell, 81:1137-1148, 1995.
Lopez-Ilasaca M., Crespo P., Pellici P.G., Gutkind J.S.*, and Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science, 275:394-397, 1997.
Crespo P., Schuebel K.E., Ostrom A.A., Gutkind J.S., and Bustelo X.R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature, 385:169-172, 1997.
Chiariello M., Marinissen M.J., and Gutkind J.S. Regulation of c-myc expression by PDGF through Rho GTPases. Nature Cell Biol., 3:580-586, 2001.
Montaner S., Sodhi A., Molinolo A., Bugge T.H., Sawai E.T., He Y., Li Y., Ray P.E., and Gutkind J.S. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell, 3:23-36, 2003.
Marinissen M.J., Chiariello M., Tanos T., Bernard O., Narumiya S., and Gutkind J.S. The small GTP-binding protein RhoA regulates c-Jun by a ROCK-JNK signaling axis, Mol. Cell, 14:29-41, 2004.
Castellone M.D., Teramoto H., Williams B.O., Druey K.M., and Gutkind J.S. Prostaglandin E2 promotes colon cancer cell growth through a novel Gs-axin-b-catenin signaling axis. Science, 310:1504-1510, 2005.
Gavard J. and Gutkind J.S. VEGF controls endothelial cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin. Nature Cell. Biol., 11:1223-1234, 2006.
Selected publications, oral cancer research:
Patel V., Senderowicz A.M., Pinto D., Ensley J., Igishi T., Sausville E.A., and Gutkind J.S. Flavopiridol, a novel CDK inhibitor, suppresses the growth of squamous cell carcinomas by inducing apoptosis. J. Clin. Invest., 102:1674-1681, 1998.
Leethanakul C., Patel V., Gillespie J., Pallante M., Ensley J.F., Liotta L.A., Emmert-Buck M., and Gutkind J.S. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene, 19:3220-3224, 2000.
Sriuranpong V., Park J.I., Amornphimoltham P., Patel P., Nelkin B.D., and Gutkind J.S. EGFR-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the IL6/gp130 cytokine system. Cancer Research, 63:2948-2956, 2003.
Amornphimoltham P., Sriuranpong V., Patel V., Benavides F., Conti C.J., Sauk J., Sausville E.A., Molinolo A.A., and Gutkind J.S., Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01, Clin. Cancer Research, 10:4029-37, 2004.
Vitale-Cross L., Amornphimoltham P., Fisher G., Molinolo A.A., and Gutkind J.S. Conditional expression of K-ras in an epithelial compartment that includes the stem-cells is sufficient to promote squamous cell carcinogenesis. Cancer Res., 64:8804-8807, 2004.
Amornphimoltham P., Patel V., Sodhi A., Nikitakis N.G., Sauk J.J., Sausville E.A., Molinolo A.A., and Gutkind J.S. mTOR, a molecular target in squamous cell carcinomas of the head and neck. Cancer Research, 65:9953-9961, 2005.
Basile J.R., Castilho R.M., Williams V.P., and Gutkind JS. Semaphorin4D provides a link between anon guidance processes and tumor-induced angiogenesis, Proc. Natl. Acad. Sci. U.S.A. 103:9017-9022, 2006.
Molinolo A.A., Hewitt S., Amornphimoltham P., Keelawat S., Rangdaeng S., Meneses García A., Raimondi A.R., Jufe R., Itoiz M., Gao Y., Saranath D., Kaleebi G.S., Yoo G.H., Leak L., Myers E.M., Shintani S., Wong D., Massey H.D., Yeudall W.A., Lonardo F., Ensley J., and Gutkind J.S. Dissecting the Akt/mTOR signaling network: Emerging results from the Head and Neck Cancer Tissue Array Initiative. Clinical Cancer Research, 13:4964-4973, 2007.
Patel V., Hood B.L., Molinolo A.A., Lee N.H, Conrads T.P., Braisted J.C., Krizman D.B., Veenstra T.D., Gutkind J.S. Proteomic analysis of laser-captured paraffin embedded tissues: A molecular portrait of head and neck cancer progression. Clin. Cancer Research, 14:1002-1014, 2008.
Amornphimoltham P., Patel V., Leelahavanichkul K., Abraham R.T, and Gutkind J.S. A retro-inhibition approach reveals a tumor cell-autonomous therapeutic response to rapamycin in head and neck squamous cell carcinomas. Cancer Research, 68:1144-1153, 2008.
Complete CV