Matrix and Morphogenesis Unit, LCDB
NATIONAL INSTITUTES OF HEALTH/NIDCR
BUILDING 30 ROOM 430
30 CONVENT DR MSC 4370
BETHESDA MD 20892-4370
Phone: (301) 496-1660
Fax: (301) 402-0897
E-mail: Dr. Matthew P. Hoffman
Research Interests
To understand the developmental mechanisms of salivary gland development with emphasis on growth factor/matrix interactions and the genetic regulation of branching morphogenesis; to investigate the role of FGFs, laminin isoforms, proteases, and to identify novel genes involved in salivary gland development.
Education
1986: BDS, University of Otago School of Dentistry, Dunedin, New Zealand
1994: PhD, University of Rochester School of Medicine and Dentistry, Department of Microbiology and Immunology, Rochester, NY
Recent Publications
Hoffman, M.P., Engbring, J.A., Nielsen, P.K., Vargas, J., Steinberg, Z., Karmand, A.J., Nomizu, M., Yamada, Y., and Kleinman, H.K. Cell type-specific differences in glycosaminoglycans modulate the biological activity of a heparin-binding peptide (RKRLQVQLSIRT) from the G domain of the laminin alpha1 chain. J. Biol. Chem. 276: 22077-22085, 2001.
Hoffman, M.P., Kidder, B.L., Steinberg, Z.L., Lakhani, S., Ho, S., Kleinman, H.K., and Larsen, M. Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development 129: 5767-5778, 2002.
Corey, D.P., Garcia-Anoveros, J., Holt, J.R., Kwan, K.Y., Lin, S.Y., Vollrath, M.A., Amalfitano, A., Cheung, E.L., Derfler, B.H., Duggan, A., Géléoc, G.S.G., Gray, P.A., Hoffman, M.P., Rehm, H.L., Tamasauskas, D., and Zhang, D.S. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432: 723-730, 2004.
Hibino, S., Shibuya, M., Hoffman, M.P., Engbring, J.A., Hossain, R., Mochizuki, M., Kudoh, S., Nomizu, M., and Kleinman, H.K. Laminin alpha5 chain metastasis- and angiogenesis-inhibiting peptide blocks fibroblast growth factor 2 activity by binding to the heparan sulfate chains of CD44. Cancer Res. 65: 10494-10501, 2005.
Fukumoto, S., Miner, J.H., Ida, H., Fukumoto, E., Yuasa, K., Miyazaki, H., Hoffman, M.P., and Yamada, Y. Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. J. Biol. Chem. 281: 5008-5016, 2006.
Larsen, M., Hoffman, M.P., Sakai, T., Neibaur, J.C., Mitchell, J.M., and Yamada, K.M. Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev. Biol. 255: 178-191, 2003.
Steinberg, Z., Myers, C., Heim, V.M., Lathrop, C.A., Rebustini, I.T., Stewart, J.S., Larsen, M., and Hoffman, M.P. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development 132: 1223-1234, 2005.
Patel, V.N., Rebustini, I.T., and Hoffman, M.P. Salivary gland branching morphogenesis. Differentiation 74: 349-364, 2006.
Wei, C., Larsen, M., Hoffman, M.P., and Yamada, K.M. Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng. 13: 721-735, 2007.
Rebustini, I.T., Patel, V.N., Stewart, J.S., Layvey, A., Georges-Labouesse, E., Miner, J.H., and Hoffman, M.P. Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling. Dev. Biol. 308: 15-29, 2007.
Patel, V.N., Knox, S.M., Likar, K.M., Lathrop, C.A., Hossain, R., Eftekhari, S., Whitelock, J.M., Elkin, M., Vlodavsky, I., and Hoffman, M.P. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development 134: 4177-4186, 2007.
Patel, V.N., Likar, K.M., Zisman-Rozen, S., Cowherd, S.N., Lassiter, K.S., Sher, I., Yates, E.A., Turnbull, J.E., Ron, D., and Hoffman, M.P. Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation. J. Biol. Chem. 283: 9308-9317, 2008.
Complete CV and Publications