Cellular and Molecular Biology, Physiology and Biotechnology Branch
Division of Basic and Translational Sciences
OBJECTIVE
We are seeking Concept Clearance for a Request for Applications (RFA). The purpose of this initiative is to stimulate cross cutting, integrative research aimed at delineating the mechanisms underlying the etiology and pathogenesis of the orofacial structures associated with Temporomandibular Joint Disorders (TMJDs).
The ultimate goal of this initiative is a systems approach, from the gene, molecule, cell to tissue and organ, that will provide the basis to better understand TMJDs and lead to the development of new insights into treatment and management of these disorders. In the context of this initiative, integrative research is defined as the combined use of approaches from several different scientific disciplines such as cell biology, physiology, neurobiology, neuroendocrinology, genetics, molecular biology and imaging technologies to probe developmental, neurological, endocrine, immune and other relevant systems.
Briefly, the initiative will focus on:
A. Investigations to systematically elucidate the underlying biological, genetic and molecular mechanisms of the TMJ structures (e.g., temporal bone, temporomandibular joint disc, ligaments and the masticatory muscles)
B. Elucidation of the pathophysiology of orofacial muscles (masticatory and facial muscle)
C. Studies of the mechanisms of orofacial pain processing, particularly TMJD associated neuropathic pain
D. Expansion of research on TMJDs by the use of contemporary biomedical techniques such as biocomputing for modeling the different components of the temporomandibular joint (TMJ) and advanced imaging techniques. Each of these technologies used alone or in combination with other assessments has the potential to reveal specific aspects of the complexities of TMJDs
E. Development of improved animal models to: i) systematically investigate each component of the TMJ and the function of sensory neurons associated with TMJ in health and diseases; ii) identify the cellular and molecular events leading to remodeling of the components of the TMJ to adapt to biomechanical changes; iii) examine specific types of TMJD associated pain disorders in males and females; and iv) identify pain-related genes and genetic correlations among pain phenotypes al stem cells.