Cellular and Molecular Biology, Physiology and Biotechnology Branch
Division of Basic and Translational Sciences
OBJECTIVE:
We are seeking Concept Clearance for a Request for Applications (RFA). The purpose of this initiative is to encourage biomimetics and tissue engineering research in the areas of orofacial tissue and organ repair and regeneration.
The ultimate goal of this initiative is a systems approach to the design and development of new biocompatible/inductive materials that can stimulate cells and tissues to regenerate and/or materials that can become integrated into the body. In the context of this initiative, integrative, multidisciplinary/interdisciplinary research approaches from several different scientific disciplines such as cell and molecular biology, genetics, physics, engineering, computer and clinical sciences and other relevant systems are encouraged.
Briefly the initiative will focus on:
A. Restoration/regeneration of teeth and periodontal tissues using biomimetic/tissue engineering approaches
B. Construction of an artificial salivary gland by application of technologies for the induction of cell differentiation and in vitro assembly of a functional acinar unit
C. Use of new diagnostic imaging technologies and development of novel molecular imaging probes as well as therapeutic strategies (e.g., autologous stem cells, 3D culture systems, "smart" polymers that mimic the extracellular matrix in serving as scaffolds for stem cell transplantation) for TMJ structure repair/regeneration