Cognition, Steroids, and Imaging in Cushings Disease

This study has been completed.

Sponsored by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00081341

Purpose

This study investigates the effects of the glucocorticoid hormone cortisol on brain structure and function. Patients with Cushing's disease are studied before and after treatment. Brain imaging and neuropsychologic tests are used to study changes in the hippocampus and thinking and learning functions as well as mood during the period of elevated cortisol. At several intervals after treatment, these are reexamined to study the degree of reversibility of the abnormalities. The contribution of cortisol as well as testosterone and estrogen to dysfunction and recovery is studied. Since elevated cortisol and dysregulation of its secretory system occurs in a significant proportion of the aged and in Alzheimers Disease and Major Depressive Disorder, these studies will help advance knowledge of the role of cortisol in these conditions.

Condition
Cushing Syndrome

MedlinePlus related topics: Cushing's Syndrome

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Cognition, Steroids, and Imaging in Cushings Disease

Eligibility

Ages Eligible for Study:	9 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion criteria:

patients with suspected Cushing's syndrome with clinical findings suggestive of Cushing's syndrome and positive screening tests (urinary free cortisol and low dose overnight dexamethasone suppression test).

Exclusion criteria: none

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00081341

Locations

United States, Michigan
General Clinical Research Center, University of Michigan Health System
Ann Arbor, Michigan, United States, 48109

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

Study ID Numbers:	51337DK
Study First Received:	April 8, 2004
Last Updated:	October 9, 2007
ClinicalTrials.gov Identifier:	NCT00081341
Health Authority:	United States: Federal Government

Study placed in the following topic categories:

Hypothalamic Diseases
Pituitary ACTH Hypersecretion
Pituitary Diseases
Cushing Syndrome
Central Nervous System Diseases

Endocrine System Diseases
Adrenal Gland Diseases
Endocrinopathy
Brain Diseases
Adrenocortical Hyperfunction

Additional relevant MeSH terms:

Hyperpituitarism
Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009