The aim of the study is to compare the efficacy of Polyethylene glycol versus sodium phosphate as purgative for colon preparation to colonoscopy, after the failure of preparation with sodium phosphate for first colonoscopy. The hypothesis tested is whether there is advantage for substituting the purgative used, as compared to repeating the colonoscopy with the same purgative.Briefly, patients whose preparation was inadequate, will be allocated randomly to a group that will receive 3L Polyethylene glycol versus a group that will receive sodium phosphate(45ccX2). Both groups will be instructed to extend low-fiber diet to 5 days. Cleanliness of the colon at colonoscopy will be assessed blindly by an experienced endoscopist.
Primary Outcome Measures:
- Colon cleanliness at the second colonoscopy [ Time Frame: within 24 hours of purgative ingestion, and within 30 minutes of colonoscopy ] [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Tolerability of purgative regimen [ Time Frame: within 24 hours of purgative ingestion ] [ Designated as safety issue: No ]
| Estimated Enrollment: |
120 |
| Study Start Date: |
January 2008 |
| Estimated Study Completion Date: |
December 2009 |
| Estimated Primary Completion Date: |
December 2009 (Final data collection date for primary outcome measure) |
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1: Active Comparator
Ingestion of 3L polyethylene Glycol
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Drug: polyethylene glycol
Single time 3 liters PEG, 250 cc every 15 minutes the day before colonoscopy
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2: Active Comparator
Ingestion of 2 doses of sodium phosphate 45 cc
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Drug: Sodium phosphate
Sodium phosphate 45cc, 2 doses 4 hours apart the day before colonoscopy
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The aim of the study is to compare the efficacy of Polyethylene glycol versus sodium phosphate as purgative for colon preparation to colonoscopy, after the failure of preparation with sodium phosphate for first colonoscopy. The hypothesis tested is whether there is advantage for substituting the purgative used, as compared to repeating the colonoscopy with the same purgative.Briefly, the study will be composed of patients whose preparation was judged to be inadequate in a first colonoscopy by an endoscopist independent of the current study. They will be allocated randomly to a group that will receive 3L Polyethylene glycol versus a group that will receive sodium phosphate(45ccX2). Both groups will be instructed to extend low-fiber diet to 5 days. Cleanliness of the colon at colonoscopy will be assessed blindly by an experienced endoscopist.
Purpose
