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Sponsors and Collaborators: |
Children's Hospital Boston Crohn's and Colitis Foundation National Institutes of Health (NIH) |
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Information provided by: | Children's Hospital Boston |
ClinicalTrials.gov Identifier: | NCT00114803 |
The hypothesis underlying this study is that nasally administered calcitonin will stabilize or improve bone mineral density in young patients with ulcerative colitis or Crohn's disease. Patients who participate will receive either calcitonin or placebo and will have their bone mineral density measured at the start, at nine months, and at 18 months of study. Participants will also receive age appropriate doses of vitamin D and calcium supplements. Other serological measures of vitamin D status will be obtained every 3 months during the study.
Condition | Intervention |
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Ulcerative Colitis Crohn's Disease |
Drug: Calcitonin nasal spray (salmon) |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Use of Intranasally Administered Calcitonin in the Treatment of Osteopenia and Osteoporosis in Children, Adolescents and Young Adults With IBD: A Pilot Study |
Estimated Enrollment: | 66 |
Study Start Date: | January 2004 |
Study Completion Date: | October 2006 |
This is an institutional, randomized, placebo-controlled, double-blind clinical trial to compare the efficacy of intranasally administered calcitonin (plus oral supplements of age-appropriate doses of calcium and vitamin D) with that of placebo nasal spray (plus oral supplements of age-appropriate doses of calcium and vitamin D) in maintaining or improving bone mineral density. Study subjects will be 8 to 22 year old patients with the diagnosis of inflammatory bowel disease (ulcerative colitis and Crohn's disease) and low bone mineral density defined as DXA z score lower than -1.0 SD. Study end-point will be at 18 months after the continuous administration of nasal calcitonin or placebo and supplements as above. Bone mineral density will be measured by dual energy X-Ray absorptiometry (DXA) at the beginning of the study, and then at 9 and 18 months. The study subjects will be evaluated clinically and nutritionally at the beginning of the study, as well as every 3 months for the duration of the study. Laboratory values relevant to calcium homeostasis and bone turnover will be obtained every 3 months.
Ages Eligible for Study: | 8 Years to 22 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | Calcitonin 1.0, CCFA #249 |
Study First Received: | June 17, 2005 |
Last Updated: | December 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00114803 |
Health Authority: | United States: Food and Drug Administration |
bone mineral density osteoporosis osteopenia |
children adolescents DXA |
Calcitonin Gastrointestinal Diseases Ulcer Colonic Diseases Osteoporosis Inflammatory Bowel Diseases Colitis, Ulcerative |
Intestinal Diseases Salmon calcitonin Calcitonin Gene-Related Peptide Digestive System Diseases Crohn Disease Gastroenteritis Colitis |
Vasodilator Agents Therapeutic Uses Physiological Effects of Drugs |
Bone Density Conservation Agents Cardiovascular Agents Pharmacologic Actions |