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Sponsored by: |
Nanjing University School of Medicine |
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Information provided by: | Nanjing University School of Medicine |
ClinicalTrials.gov Identifier: | NCT00801268 |
Triptolide has been approve effective in animal model
Condition | Intervention |
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Polycystic Kidney |
Drug: tripterygium wilfordii Drug: Emodin Drug: Losartan |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Factorial Assignment, Safety/Efficacy Study |
Official Title: | Randomized Clinical Trial of Triptolide Woldifii for Autosomal Dominant Polycystic Kidney Disease (ADPKD) |
Estimated Enrollment: | 150 |
Study Start Date: | November 2008 |
Estimated Study Completion Date: | June 2011 |
Estimated Primary Completion Date: | June 2011 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Drug: Experimental
Losartan
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Drug: tripterygium wilfordii
TW,60mg/d
Drug: Emodin
Emodin
Drug: Losartan
100mg/d
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Randomized
Ages Eligible for Study: | 15 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Yao Xiaodan, Master | 00862586030066 | yaoxiaodan@hotmail.com |
China, Jiangsu | |
Liu ZH, Yao XD,Chen X,Hu YL | Recruiting |
Nanjing, Jiangsu, China, 210002 | |
Contact: XIAO-DAN YAO, Dr. 00862586030066 yaoxiaodan@hotmail.com | |
Yao Xiaodan | Recruiting |
Nanjing, Jiangsu, China, 210002 | |
Contact: XD YAO 00862586030066 yaoxiaodan@hotmail.com |
Principal Investigator: | Liu Zhihong, Master | Research Institute of Nephrology, Jinling Hospital |
Responsible Party: | Research Institute of Nephrology, Jinling Hospital,Jinling Hospital, ( Research Institute of Nephrology, Jinling Hospital,Jinling Hospital, ) |
Study ID Numbers: | NJCT-0802 |
Study First Received: | November 25, 2008 |
Last Updated: | December 2, 2008 |
ClinicalTrials.gov Identifier: | NCT00801268 |
Health Authority: | China: State Food and Drug Administration |
polycystic kidney disease tripterygium wilfordii |
Losartan Urologic Diseases Emodin Triptolide Polycystic Kidney, Autosomal Dominant |
Kidney Diseases, Cystic Polycystic Kidney Diseases Kidney Diseases Angiotensin II |
Immunologic Factors Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Contraceptive Agents Physiological Effects of Drugs Gastrointestinal Agents Cathartics Enzyme Inhibitors Cardiovascular Agents Reproductive Control Agents Antihypertensive Agents |
Contraceptive Agents, Male Protein Kinase Inhibitors Immunosuppressive Agents Pharmacologic Actions Angiotensin II Type 1 Receptor Blockers Therapeutic Uses Antispermatogenic Agents Anti-Arrhythmia Agents Antineoplastic Agents, Alkylating Alkylating Agents |