Adult men and women who are scheduled to undergo qualified surgeries that are likely to require the use of an active topical hemostatic agent.

Inclusion Criteria:

To be eligible for this study, a subject MUST meet the following inclusion criteria:

• Must have undergone any one (or more) of the following surgical procedures within the past 4 years, but not less than 30 days before the study surgery: lumbar/cervical discectomy, lumbar/cervical laminectomy, microdiscectomy, shunt procedures, craniotomy, peripheral nerve surgical procedures, carotid artery surgery, repair of aneurysm, hip or other joint replacement, open repair of bone fracture, open spine procedures, creation of dialysis access, lower or upper extremity vascular bypass, skin grafting, burn wound debridement, facelift, abdominoplasty;
• Must be scheduled to undergo any one of the following surgical procedures, which is likely to require the use of topical thrombin, but is unlikely to require allogenic blood transfusion: lumbar/cervical discectomy, lumbar/cervical laminectomy, microdiscectomy, shunt procedures, craniotomy, peripheral nerve surgical procedures, carotid artery surgery, repair of aneurysm, hip or other joint replacement, open repair of bone fracture, open spine procedures, creation of dialysis access, lower or upper extremity revascularization, skin grafting, burn wound debridement, facelift, abdominoplasty;
• Must be 18 years of age or older;
• Must be capable and willing to provide written informed consent.

Exclusion Criteria:

To be eligible for this study, a subject MUST NOT meet any of the following exclusion criteria:

• Clinical history or clinical laboratory evidence of prior sensitivity to topical bovine thrombin, any of its components and/or other materials of bovine origin;
• A female who is pregnant, nursing, or of childbearing potential while not practicing effective contraceptive methods and women who have been on hormonal contraceptives within 30 days of the surgical procedure;
• Medical condition or personal circumstances that will prevent participation in and completion of the follow-up visits at 48 hours, 4 weeks, and 8 weeks post-surgery;
• Currently participating in or has participated in (within 30 days prior to inclusion in this trial) another clinical trial of an investigational drug, biologic, device, or procedure;
• Known hematologic or medical condition that impedes/prolongs coagulation;
• Screening fibrinogen level less than the lower limit of normal based on the local laboratory ranges;
• Proposed exposure during the trial or previous known exposure to topical thrombin other than THROMBIN-JMI®;
• Prothrombin time, aPTT or TT outside of normal reference values at Baseline (e.g., Screening Visit).
• Planned use of therapeutic doses of intravenous heparin or low molecular weight heparin within 48 hours following surgery;
• Use of warfarin (Coumadin) within 5 days prior to surgery, or within 48 hours after surgery.