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Sponsors and Collaborators: |
Lahey Clinic Tufts Medical Center |
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Information provided by: | Lahey Clinic |
ClinicalTrials.gov Identifier: | NCT00774657 |
This preliminary study will compare the effectiveness of two-dimensional and three-dimensional echocardiographic measurements of wall thickness and left ventricular mass in patients with Aortic Stenosis
Condition |
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Aortic Stenosis |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Patterns Of Left Ventricular Remodeling In Patients With Aortic Stenosis Assessed By Two-Dimensional And Three-Dimensional Echocardiography |
Estimated Enrollment: | 60 |
Study Start Date: | September 2008 |
Estimated Study Completion Date: | November 2010 |
Estimated Primary Completion Date: | October 2009 (Final data collection date for primary outcome measure) |
This study will evaluate left ventricular patterns of remodeling and hypertrophy in patients with aortic stenosis, and compare two-dimensional echocardiography measurements (wall thickness) with three-dimensional echocardiography data(left ventricular mass). Along with a second objective to assess Doppler diastolic filling indices associated with the various patterns of left ventricular remodeling.
Previous studies(see reference list) were primarily derived from two-dimensional echo data set(based on wall thickness). Various patterns of left ventricular remodeling have been described in response to increased pressure overload.
Three-dimensional echocardiography is a relatively new technique that is being increasingly used in the Echocardiography Lab in selected patients. This technique holds promise of being more accurate for volume-related measurements than the standard 2-dimensional echocardiography techniques.
Ages Eligible for Study: | 18 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Lahey Clinic patients who have been referred to the echocardiography lab for clinical indications, found to have a aortic stenosis
Inclusion Criteria:
Exclusion Criteria:
United States, Massachusetts | |
Lahey Clinic, Inc. | |
Burlington, Massachusetts, United States, 01805 |
Principal Investigator: | Sherif B. Labib, M.D. | Lahey Clinic, Inc. |
Responsible Party: | Lahey Clinic, Inc. ( Sherif B. Labib, M.D. ) |
Study ID Numbers: | 2008-090 |
Study First Received: | October 16, 2008 |
Last Updated: | October 16, 2008 |
ClinicalTrials.gov Identifier: | NCT00774657 |
Health Authority: | United States: Institutional Review Board |
Aortic Stenosis Valvular heart disease Heart disease |
Cardiovascular disease Two dimensional echocardiography Three dimensional echocardiography |
Pathological Conditions, Anatomical Heart Diseases Constriction, Pathologic |
Aortic valve stenosis Aortic Valve Stenosis Heart Valve Diseases |
Cardiovascular Diseases Ventricular Outflow Obstruction |