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Sponsored by: |
Guidant Corporation |
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Information provided by: | Guidant Corporation |
ClinicalTrials.gov Identifier: | NCT00305526 |
This protocol will evaluate the effect of cardiac resynchronization therapy (CRT) combined with beta-blocker therapy in patients with symptomatic heart failure in whom beta-blocker therapy was either not tolerated or could not be up titrated to optimal doses before CRT. Cardiac resynchronization therapy will be combined with automatic implantable cardioverter defibrillator (AICD, CRT-D) as it has been shown to be associated with an improvement in prognosis in the patients with left ventricular systolic dysfunction and heart failure.
Condition | Intervention | Phase |
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Heart Failure |
Device: Contak Renewal (CRT-D) |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Resynchronisation and Beta-Blocker European Trial |
Estimated Enrollment: | 354 |
Study Start Date: | April 2006 |
Study Completion Date: | July 2007 |
The purpose of this investigation is to evaluate the effect of CRT combined with beta-blocker therapy in patients with symptomatic heart failure in whom beta-blocker therapy was either not tolerated or could not be up-titrated to optimal doses before CRT.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Italy | |
Spedali Civili di Brescia | |
Brescia, Italy, 25100 | |
Istituto clinico Humanitas | |
Milano, Italy | |
Switzerland | |
Cardiocentro Ticino | |
Lugano, Switzerland |
Principal Investigator: | Antonio Curnis, MD | Spedali Civili di Brescia, Brescia, Italy |
Study ID Numbers: | REBEAT 1.5 |
Study First Received: | March 21, 2006 |
Last Updated: | August 8, 2007 |
ClinicalTrials.gov Identifier: | NCT00305526 |
Health Authority: | Italy: Ministry of Health |
Heart Failure Heart Diseases |
Cardiovascular Diseases |