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| Sponsored by: |
National Eye Institute (NEI) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00304967 |
Purpose
This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye. It detects proteins in the lens, identifying early changes that may make the device useful in future cataract studies. This study will use DLS to examine the characteristics of proteins in healthy young lenses that can be used for comparison with lenses in older people and people with cataracts.
Normal volunteers aged 5 to 21 years may be eligible for this study. Participants undergo the following procedures:
Medical history
Eye examination with dilation to include:
| Condition |
|---|
|
Healthy |
| Study Type: | Observational |
| Official Title: | A Study of Crystalline Proteins in Young Normal Lenses Using the NASA-NEI Dynamic Light Scattering (DLS) Device |
| Estimated Enrollment: | 30 |
| Study Start Date: | March 2006 |
| Estimated Study Completion Date: | March 2007 |
The NASA-NEI Dynamic Light Scattering (DLS) device detects early molecular lens changes before clinical means are able to detect any lens changes in animal and limited human studies. This ability will make it very useful in future clinical studies of cataract etiology as well as treatment. A recently concluded clinical cross sectional study of lenses (in vivo) using the DLS device showed good reproducibility and good correlation with clinical cataract grading. It also detected remarkable changes in the lens crystalline proteins with aging and with cataract formation. We therefore propose to study the characteristics of the crystalline proteins in pristine young normal lenses with DLS for comparison with aging and cataractous lens findings. We will examine 30 young normal subjects, perform undilated eye examinations, and obtain DLS measurements of their lenses. We will then use these DLS measurements for comparison with the previously obtained aging and cataract DLS measurements, to obtain normative data for future lens and cataract clinical studies.
Eligibility| Ages Eligible for Study: | 5 Years to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
The study will enroll 30 normal control subjects, aged 5-21 years. Eligible participants must have normal clear lenses as determined by the eye examination.
EXCLUSION CRITERIA
Individuals who cannot cooperate or keep still for the DLS measurements will be excluded.
Contacts and Locations More Information
| Study ID Numbers: | 060117, 06-EI-0117 |
| Study First Received: | March 18, 2006 |
| Last Updated: | March 5, 2008 |
| ClinicalTrials.gov Identifier: | NCT00304967 |
| Health Authority: | United States: Federal Government |
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Cataract Normal Lenses Lens Crystallines Dynamic or Quasielastic Light Scattering (DLS) |
Eye Examinations Healthy Volunteer HV Eye Examination |
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Cataract Healthy |
