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Sponsored by: |
Centers for Disease Control and Prevention |
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Information provided by: | Centers for Disease Control and Prevention |
ClinicalTrials.gov Identifier: | NCT00446628 |
The purpose of this study is to understand the spread of influenza (flu) in schools and households with elementary (K-5) school children, and develop ways to reduce the flu using non-pharmaceutical means.
Condition | Intervention |
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Influenza Epidemiology Prevention Pandemic |
Behavioral: behaviors reducing spread of influenza |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Pittsburgh Influenza Prevention Project |
Estimated Enrollment: | 3800 |
Study Start Date: | January 2007 |
Estimated Study Completion Date: | September 2008 |
Pandemic influenza threatens to cause substantial disability, death, and societal disruption and to overwhelm health care systems in the United States and around the world. Because effective vaccines may not be available during the initial months of a pandemic, and because anti-viral medication is both largely ineffective and in short supply, non-pharmacological personal protection and behavioral changes may be the only means to combat the epidemic. In our computational modeling work (through the Models of Infectious Disease Agent Study network), we have shown the potential value of multiple targeted and layered non-pharmacological interventions in blunting the peak impact and slowing of a pandemic (Nature, in press).
Phase 1 of the project will be a pilot study in two elementary schools in the City of Pittsburgh. The project has already obtained agreement to collaborate from the Pittsburgh Public School System and we have assembled a multi-disciplinary team of epidemiologists, systems analysts, modelers, community and minority health workers, and virologists to implement the project. Phase one was in 2 schools.
Phase 2 will be similar to Phase 1 with the addition of additional schools and application of a "hygiene" intervention to selected schools and families. Phase 2 is in 10 schools with 3800 students.
Specific aims (year 02):
Primary
Assess adoption of NPI behaviors and activities in classrooms of intervention schools.
Secondary: Home-Based
Assess adherence of families of enrolled school children with influenza to isolation-related NPI behaviors and activities.
Tertiary
Ages Eligible for Study: | 6 Months and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
3800 K-5 elementary school students in 10 schools
Inclusion Criteria (student):
Inclusion Criteria (household members):
Exclusion Criteria (student):
Exclusion Criteria (household):
United States, Pennsylvania | |
University of Pittsburgh | |
Pittsburgh, Pennsylvania, United States, 15213 |
Principal Investigator: | Donald S Burke, MD | University of Pittsburgh |
Principal Investigator: | Sam Stebbins, MD, MPH | University of Pittsburgh School of Public Health |
Responsible Party: | Graduate School of Public Health; Univerity of Pittsburgh ( Donald Burke, MD, Principle Investigator ) |
Study ID Numbers: | CDC-NCPDCID-CC-0612047, CDC-U01 CI000435-01 |
Study First Received: | March 12, 2007 |
Last Updated: | July 30, 2008 |
ClinicalTrials.gov Identifier: | NCT00446628 |
Health Authority: | United States: Federal Government |
Non-pharmaceutical influenza pandemic |
Virus Diseases Respiratory Tract Diseases Respiratory Tract Infections Influenza, Human Orthomyxoviridae Infections |
RNA Virus Infections |