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Sponsored by: |
University of Oklahoma |
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Information provided by: | University of Oklahoma |
ClinicalTrials.gov Identifier: | NCT00618683 |
The purpose of this study is to determine/identify what mechanisms/factors are involved with regard to AV nodal reentrant tachycardia.
Condition | Intervention |
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Tachycardia, Atrioventricular Nodal Reentry |
Procedure: Cardiac Invasive Electrophysiological Study |
Study Type: | Interventional |
Study Design: | Diagnostic, Open Label, Single Group Assignment, Efficacy Study |
Official Title: | Localization of the Anterograde and Retrograde Components of the Reentrant Circuit of AV Nodal Reentrant Tachycardia |
Estimated Enrollment: | 100 |
Study Start Date: | March 2004 |
Estimated Study Completion Date: | March 2010 |
Estimated Primary Completion Date: | March 2010 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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Study Arm
Mapping and Ablation
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Procedure: Cardiac Invasive Electrophysiological Study
Mapping and localizing of the components of the reentrant circuit as part of the Electrophysiological Study
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HYPOTHESES:
DATA ANALYSIS/STATISTICS:
Resetting and Mapping of AV nodal reentrant tachycardia:
Pacing will be analyzed to see at which sites, the tachycardia can be reset by the latest extra-stimuli (i.e., with the least advancement in local activation). The coupling interval will be compared to the latest extra-stimulus capable of resetting (advancing) the tachycardia from the postero-septal tricuspid annulus.
Ablation Results:
The patients will act as their own reference, since the standard ablation technique in the postero-septal space is being performed first and tested for efficacy. The McNemar test will be applied to compare the efficacy of ablation at the postero-septal tricuspid annulus alone (standard ablation), with the efficacy of this ablation plus ablation within the coronary sinus. From our initial observations, It is anticipated that the additional ablation in the coronary sinus will increase the efficacy of the procedure from <95% to >98%, such that 100 cases should provide sufficient data to reach statistical significance.
Ages Eligible for Study: | 16 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Deborah Lockwood, M.D. | 405-271 9696 ext 37531 | deborah-lockwood@ouhsc.edu |
Contact: Caroline Hilferink, RN, MPH | 405-271 9696 ext 37525 | caroline-hilferink@ouhsc.edu |
United States, Oklahoma | |
The University of Oklahoma Health Sciences Center | Recruiting |
Oklahoma City, Oklahoma, United States, 73104 | |
Contact: Caroline Hilferink, RN, MPH 405-271-9696 ext 37525 caroline-hilferink@ouhsc.edu | |
Contact: kathy Drennan, RN 405-271 2299 kathy-drennan@ouhsc.edu | |
Principal Investigator: Deborah Lockwood, M.D. |
Principal Investigator: | Deborah Lockwood, M.D. | University of Oklahoma |
Responsible Party: | University of Oklahoma ( Dr. Deborah Lockwood ) |
Study ID Numbers: | 11255, AHA |
Study First Received: | February 7, 2008 |
Last Updated: | August 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00618683 |
Health Authority: | United States: Institutional Review Board |
AVNRT Atrioventricular nodal reentrant circuit nodal reentrant tachycardia Paroxysmal supraventricular tachycardia |
Tachycardia, Supraventricular Heart Diseases Tachycardia Tachycardia, Atrioventricular Nodal Reentry Arrhythmias, Cardiac |
Pathologic Processes Cardiovascular Diseases Tachycardia, Reciprocating |