Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients - Full Text View

Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients (SOM)

This study is currently recruiting participants.

Verified by Cliniques universitaires Saint-Luc- Université Catholique de Louvain, July 2008

Sponsored by:	Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Information provided by:	Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ClinicalTrials.gov Identifier:	NCT00716222

Purpose

There is a well-documented relationship between short sleep duration and high body mass index (BMI). The mechanism linking short sleep duration and weight gain is unknown. Current studies in healthy young volunteers have shown that experimental sleep restriction is associated with dysregulation of the neuroendocrine control of appetite and with alterations in glucose metabolism. The goal of our study is to determine the metabolic and hormonal modifications induced by chronic sleep curtailment in obese adolescents and young adults and to observe if short sleep is a negative prognostic factor in their weight evolution.

Condition
Obesity Sleep Disorders

MedlinePlus related topics: Obesity Obesity in Children Sleep Disorders

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Cross-Sectional
Official Title:	Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients

Further study details as provided by Cliniques universitaires Saint-Luc- Université Catholique de Louvain:

Estimated Enrollment:	70
Study Start Date:	May 2008
Estimated Study Completion Date:	May 2009

Groups/Cohorts
1 Obese adolescent and young adult with sleep disorder
2 Obese adolescent and young adult without sleep disorder
3 Lean adolescent and young adult with sleep disorder

Detailed Description:

The main purpose of the study is investigate whether the concentrations of 2 hormones that regulate appetite (leptin, ghrelin), cytokines (TNF-a, IL-6) and CRP are modified in obese adolescents and young adults who had sleep disorders in comparison to obese adolescents and young adults who sleep longer.

Eligibility

Ages Eligible for Study:	13 Years to 25 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients of the output clinics in the endocrinology and pediatric endocrinology departments at the university hospital.

Criteria

Inclusion Criteria:

13-25 years old
IMC > 30 kg/m2 (If adolescents aged under 18 years: BMI equivalent to a BMI for age and sex to a BMI of 30, according to the Cole et al. obesity criteria).

Exclusion Criteria:

Infection
Liver disease
Chronic inflammatory disease
Endocrine disease
Use of drugs that alter the sensitivity of insulin

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00716222

Contacts

Contact: Veronique VB Beauloye, PhD

+3227641370

Veronique.Beauloye@uclouvain.be

Locations

Belgium
Cliniques Universitaires Saint Luc	Recruiting
Brussels, Belgium, 1200
Contact: Veronique VB Beauloye, PhD +3227641370 Veronique.Beauloye@uclouvain.be

Sponsors and Collaborators

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Investigators

Principal Investigator:

Veronique Beauloye, PhD

Cliniques Universitaires Saint Luc

More Information

Responsible Party:	Cliniques universitaires Saint-Luc ( M.D. PhD V Beauloye )
Study ID Numbers:	B40320084032
Study First Received:	July 15, 2008
Last Updated:	July 15, 2008
ClinicalTrials.gov Identifier:	NCT00716222
Health Authority:	Belgium: Institutional Review Board

Study placed in the following topic categories:

Body Weight
Signs and Symptoms
Obesity
Mental Disorders
Neurologic Manifestations

Nutrition Disorders
Sleep Disorders
Overweight
Overnutrition

Additional relevant MeSH terms:

Pathologic Processes
Disease
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009