Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients

This study is currently recruiting participants.

Verified by Policlinico Hospital, November 2008

Sponsored by:	Policlinico Hospital
Information provided by:	Policlinico Hospital
ClinicalTrials.gov Identifier:	NCT00267241

Purpose

The aim of this study is to evaluate the effects in terms of gas exchange, respiratory mechanics and comfort of breathing, of different assisted mechanical ventilation in ALI/ARDS patients.

Condition	Intervention
Respiratory Distress Syndrome, Adult	Other: Mechanical Ventilation

MedlinePlus related topics: Gas

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Single Blind (Subject), Dose Comparison, Single Group Assignment, Efficacy Study
Official Title:	Effects of Different Assisted Mechanical Ventilation in ALI/ARDS Patients

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:

Gas exchange and respiratory mechanics [ Time Frame: 5 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment:	20
Study Start Date:	December 2005
Estimated Study Completion Date:	March 2009
Estimated Primary Completion Date:	March 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental ALI/ARDS patients	Other: Mechanical Ventilation Four different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation)

Detailed Description:

ALI/ARDS patients (during assisted ventilation) will be ventilated with different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation) and gas exchange, comfort of breathing, respiratory mechanics and pattern of breathing will be measured.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients with ALI/ARDS

Exclusion Criteria:

COPD patients
Barotrauma
Hemodynamic instability
Age less than 18

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00267241

Contacts

Contact: Davide Chiumello, MD

39-025-503-3237

chiumello@libero.it

Locations

Italy
Policlinico Hospital	Recruiting
Milano, Italy, 20122
Contact: Davide Chiumello, MD 39-025-503-3237 chiumello@libero.it
Principal Investigator: Davide Chiumello, MD

Sponsors and Collaborators

Policlinico Hospital

Investigators

Principal Investigator:

Davide Chiumello, MD

Policlinico Hospital

More Information

Responsible Party:	Policlinico Hospital ( Davide Chiumello )
Study ID Numbers:	1600
Study First Received:	December 19, 2005
Last Updated:	November 13, 2008
ClinicalTrials.gov Identifier:	NCT00267241
Health Authority:	Italy: National Monitoring Centre for Clinical Trials - Ministry of Health

Keywords provided by Policlinico Hospital:

ARDS
ALI
respiratory mechanics
gas exchange
assisted ventilation

Study placed in the following topic categories:

Respiratory Tract Diseases
Lung Diseases
Respiration Disorders
Respiratory Distress Syndrome, Adult
Acute respiratory distress syndrome

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome

ClinicalTrials.gov processed this record on January 16, 2009