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Sponsors and Collaborators: |
Mount Sinai School of Medicine Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
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Information provided by: | Mount Sinai School of Medicine |
ClinicalTrials.gov Identifier: | NCT00589368 |
The purpose of this study is to examine if the strong hand can assist in the recovery of muscle function in the weak hand after a stroke.
Condition | Intervention |
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Stroke With Hemiparesis |
Behavioral: Transfer of grasp control across hands |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | Interhemispheric Transfer of Grasp Control After Stroke |
Estimated Enrollment: | 40 |
Study Start Date: | May 2006 |
Estimated Study Completion Date: | March 2011 |
Estimated Primary Completion Date: | March 2011 (Final data collection date for primary outcome measure) |
Groups/Cohorts | Assigned Interventions |
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1
stroke group
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Behavioral: Transfer of grasp control across hands
transfer of planning and execution of grasp across hands in terms of its effect on fingertip forces, and the timing and magnitude of muscle contraction in patients with hemiparesis and healthy controls
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2
control group
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Behavioral: Transfer of grasp control across hands
transfer of planning and execution of grasp across hands in terms of its effect on fingertip forces, and the timing and magnitude of muscle contraction in patients with hemiparesis and healthy controls
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Hemiparesis is the most common motor impairment after stroke. Persistent deficits in the distal upper extremity lead to impaired hand function and disability in Activities of Daily Living, accruing enormous costs in terms of health care services and lost productivity. The mechanisms of recovery of hand motor function after stroke are poorly understood, and the protocols used in clinical practice lack a solid scientific rationale. Prior work has shown that grasping with the non-involved hand may assist in planning of grasp with the involved hand after stroke. The goal of the proposed project is to investigate the type and nature of information relayed across the hemispheres by prior manipulation with the non-involved hand to improve planning and control of grasp with the involved hand. Psychophysical methods using a grip instrument will be used to examine the type of information necessary for planning of grasp, and quantitative surface electromyography will be used to investigate the contribution of improved planning to neuromuscular control of grasp. Integration of these methods in the study of grasp control will clarify the neural mechanisms underlying hand dysfunction, and facilitate the development of rational therapeutic protocols for upper extremity rehabilitation after stroke.
Ages Eligible for Study: | 21 Years to 90 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Subjects with stroke will be recruited from the inpatient and outpatient Rehabilitation units at the Mount Sinai Medical Center and from referrals by community rehabilitation physicians and neurologists. Control subjects will be recruited by public advertisement in the New York City area. There are no exclusions based on gender or ethnic groups.
Inclusion Criteria:
Exclusion Criteria:
Contact: Preeti Raghavan, MD | 212-241-9592 | preeti.raghavan@mountsinai.org |
Contact: Eddie Li | 212-241-7182 |
United States, New York | |
Mount Sinai School of Medicine | Recruiting |
New York, New York, United States, 10029 | |
Principal Investigator: Preeti Raghavan, MD |
Principal Investigator: | Preeti Raghavan, MD | Mount Sinai School of Medicine |
Responsible Party: | Mount Sinai School of Medicine ( Preeti Raghavan, MD ) |
Study ID Numbers: | 04-0585, K23 HD049472 |
Study First Received: | December 24, 2007 |
Last Updated: | December 24, 2007 |
ClinicalTrials.gov Identifier: | NCT00589368 |
Health Authority: | United States: Institutional Review Board |
Brain Infarction pathology physiopathology psychology rehabilitation Fingers Grasp Functional Laterality |
Hand Strength Neuronal Plasticity Psychomotor Performance Biomechanis Touch Weight-Bearing |
Body Weight Signs and Symptoms Paresis Cerebral Infarction Stroke Vascular Diseases |
Central Nervous System Diseases Neurologic Manifestations Brain Infarction Brain Diseases Infarction Cerebrovascular Disorders |
Nervous System Diseases Cardiovascular Diseases |