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Sponsored by: |
United States Army Institute of Surgical Research |
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Information provided by: | United States Army Institute of Surgical Research |
ClinicalTrials.gov Identifier: | NCT00588796 |
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
Condition |
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Severe Burns Major Trauma |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries |
Estimated Enrollment: | 30 |
Study Start Date: | February 2005 |
Estimated Study Completion Date: | December 2009 |
Estimated Primary Completion Date: | August 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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A
Healthy
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B
Burn
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C
Trauma
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In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Burn patients Trauma patients Healthy Volunteers
Inclusion Criteria:
Exclusion Criteria:
Contact: Wenjun Z Martini, PhD | 210-916-4573 | wenjun.martini@amedd.army.mil |
Contact: Annette R McClinton, RN, MA | 210-916-2834 | annette.mcclinton@amedd.army.mil |
United States, Texas | |
U.S. Army Institute of Surgical Research | Recruiting |
Fort Sam Houston, Texas, United States, 78234 | |
Contact: Annette R McClinton, RN, MA 210-916-2834 annette.mcclinton@amedd.army.mil | |
Contact: Lynn C Platteborze, MS 210-916-9531 lynn.platteborze@amedd.army.mil | |
Principal Investigator: Wenjun Z Martini, PhD |
Principal Investigator: | Wenjun Z Martini, PhD | United States Army Institute of Surgical Research |
Responsible Party: | USAISR ( Wenjun Z. Martini, PhD ) |
Study ID Numbers: | H-04-017 |
Study First Received: | December 25, 2007 |
Last Updated: | July 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00588796 |
Health Authority: | United States: Federal Government |
fibrinogen burns trauma metabolism |
Burns Wounds and Injuries Disorders of Environmental Origin |