Corneal Barrier Function With Multi-Purpose Solutions - Full Text View

Sponsors and Collaborators:	Southern California College of Optometry Alcon Research
Information provided by:	Southern California College of Optometry
ClinicalTrials.gov Identifier:	NCT00407238

Purpose

The purpose of this study is to evaluate the effect on epithelial barrier function of three emarketed multi-purpose solution applied to the human eye with hydrogel lenses as during normal regimen use.

Condition	Intervention
Contact Lens Care	Device: Multi-purpose solutions (polyquaternium-1 and PHMB)

MedlinePlus related topics: Eye Wear

Drug Information available for: Polyquaternium 1

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Active Control, Crossover Assignment, Safety Study
Official Title:	Comparison of Human Corneal Barrier Function With Three Marketed Multi-Purpose Solutions

Further study details as provided by Southern California College of Optometry:

Primary Outcome Measures:

Ratio of fluorescein dye penetration rate of test eye vs. control

Secondary Outcome Measures:

Corneal fluorescein staining

Estimated Enrollment:	25
Study Start Date:	November 2006
Study Completion Date:	March 2007

Detailed Description:

The purpose of this study is to evaluate the effect on epithelial barrier function of three emarketed multi-purpose solution applied to the human eye with hydrogel lenses as during normal regimen use.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Adapted daily soft contact lens wearers, at least 18 years of age, vision correctable to 20/40

Exclusion Criteria:

Ocular or systemic allergies, abnormalities of the cornea, active ocular infection, prior keratorefractive surgery, use of ocular medications

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00407238

Locations

United States, California
Southern California College of Optometry
Fullerton, California, United States, 92831

Sponsors and Collaborators

Southern California College of Optometry

Alcon Research

Investigators

Principal Investigator:

Jerry R Paugh, OD, PhD

Southern California College of Optometry

More Information

Study ID Numbers:	6-08
Study First Received:	November 17, 2006
Last Updated:	October 21, 2007
ClinicalTrials.gov Identifier:	NCT00407238
Health Authority:	United States: Institutional Review Board

Keywords provided by Southern California College of Optometry:

barrier function, multi-purpose solutions, silicone hydrogel contact lenses

ClinicalTrials.gov processed this record on January 16, 2009