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Sponsored by: |
University of British Columbia |
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Information provided by: | University of British Columbia |
ClinicalTrials.gov Identifier: | NCT00175578 |
Promising new technology exists to examine small proteins that are shed by cancers into the blood stream. The purpose of this study is to see if there are differences in the proteins and protein levels in blood from individuals with early stage lung cancer compared to healthy adults.
Condition |
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Non-Small Cell Lung Cancer |
Study Type: | Observational |
Study Design: | Cohort, Prospective |
Official Title: | Differences in SELDI Produced Serum Protein Profiles of Non-Small Cell Lung Cancer Patients Compared to Healthy Heavy Smoking Adults |
Estimated Enrollment: | 220 |
Study Start Date: | May 2005 |
A prospective longitudinal patient-based pilot study is proposed whereby surfaced enhanced laser desorption ionization time-of-flight mass spectroscopy (SELDI-TOF-MS) will be used to discover and validate serum proteomic expression profiles diagnostic of early lung cancer. A unique approach will be used to compare the serum proteomic expression profiles of patients with non-small cell lung cancer compared to healthy heavy smoking adults, as well as differences before and after anatomic pulmonary resection with curative intent. Discriminatory proteins will be selected by their differential expression before compared to after surgical removal of a tumor. The protein profile of blood obtained from the draining pulmonary vein at the time of resection will be used to identify materials potentially shed by the tumor that may serve as biomarkers in peripheral blood. The serum samples will be used to develop a training data set and then a test set for validation using a class prediction model. Candidate proteomic patterns will then serve as a basis for a larger prospective multi-centre clinical trial.
Ages Eligible for Study: | 45 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Patients with non-small cell lung cancer and healthy heavy smoking adults.
Inclusion Criteria:
Contact: Jennifer Rattenbury | 604-875-4111 ext 62183 | jrattenbury@shaw.ca |
Canada, British Columbia | |
Vancouver General Hospital BC Cancer Agency | Recruiting |
Vancouver, British Columbia, Canada | |
Contact: Jennifer Rattenbury 604-875-4111 ext 62183 | |
Principal Investigator: John Yee, MD |
Principal Investigator: | John Yee, MD | University of British Columbia |
Responsible Party: | University of British Columbia ( Dr. John Yee ) |
Study ID Numbers: | C04-0640 |
Study First Received: | September 13, 2005 |
Last Updated: | September 22, 2008 |
ClinicalTrials.gov Identifier: | NCT00175578 |
Health Authority: | Canada: Health Canada |
Early stage (0/I) non-small cell lung cancer |
Thoracic Neoplasms Smoking Non-small cell lung cancer Respiratory Tract Diseases Lung Neoplasms |
Lung Diseases Healthy Carcinoma, Non-Small-Cell Lung Neoplasms, Glandular and Epithelial Carcinoma |
Respiratory Tract Neoplasms Neoplasms Neoplasms by Site Neoplasms by Histologic Type |