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Sponsors and Collaborators: |
Anand, Sonia, M.D. Canadian Institutes of Health Research (CIHR) Heart and Stroke Foundation of Ontario |
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Information provided by: | Warfarin and Antiplatelet Vascular Evaluation |
ClinicalTrials.gov Identifier: | NCT00125671 |
The purpose of this study is to evaluate whether the addition of warfarin (a blood-thinning medication) to an antiplatelet therapy like aspirin is better than antiplatelet therapy alone (i.e. usual treatment) for the prevention of leg surgery, heart attacks, stroke and death in people with peripheral vascular disease.
Condition | Intervention | Phase |
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Peripheral Vascular Diseases Cardiovascular Diseases |
Drug: Warfarin |
Phase III |
Study Type: | Interventional |
Study Design: | Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | A Phase III Randomized Trial of Warfarin Plus Antiplatelet Therapy Versus Antiplatelet Therapy Alone in Patients With Peripheral Vascular Disease |
Estimated Enrollment: | 2400 |
Study Start Date: | January 2000 |
Estimated Study Completion Date: | April 2006 |
Atherosclerosis is the underlying cause of peripheral vascular disease (PVD) of the lower extremities, and leads to intermittent claudication, leg ulceration and gangrene. More importantly, symptomatic PVD is an ominous sign that widespread atherosclerosis is present and patients with this condition suffer a threefold increase in myocardial infarction (MI), stroke, and CV death. These CV events are a consequence of rupture of an atherosclerotic plaque, which leads to platelet activation and thrombin generation, thrombus formation and occlusion of a critical blood vessel. Antiplatelet therapy has been clearly demonstrated to reduce major CV events. It is also reasonable to expect that this process may be further attenuated by the addition of an anti-thrombin agent (such as warfarin) in combination with antiplatelet agents.
WAVE is a large, international, multicentre, randomized clinical trial in high-risk PVD patients to evaluate the additional benefit of moderate intensity warfarin (target INR of 2.4-3.0) to antiplatelet therapy compared to antiplatelet therapy alone in reducing serious cardiovascular events.
There are currently 80 active centres following participants in Canada, Poland, Australia, Hungary, China, Ukraine, and the Netherlands. Following randomization to one of the two treatment groups, participants will require clinic or phone follow-up visits every 3 months for 2.5 or 3.5 years. For participants on warfarin, INRs will be measured monthly or more frequently if required. For participants who stop warfarin therapy prematurely, every attempt will be made to have them restart it
Ages Eligible for Study: | 35 Years to 85 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Temporary:
Potential subjects will be temporarily excluded if they need to undergo:
Permanent:
Subjects will be excluded for the following:
Canada, Ontario | |
Population Health Research Institute, McMaster University | |
Hamilton, Ontario, Canada, L8L 2X2 |
Principal Investigator: | Sonia Anand, MD PhD FRCPc | Population Health Research Institute, McMaster University |
Study ID Numbers: | MCT-37413, T4913 |
Study First Received: | July 29, 2005 |
Last Updated: | March 23, 2006 |
ClinicalTrials.gov Identifier: | NCT00125671 |
Health Authority: | Canada: Health Canada |
Warfarin and Antiplatelet Vascular Evaluation Peripheral vascular disease Atherosclerosis cardiovascular events Ischemia |
oral anticoagulants low ankle-brachial index moderate intensity warfarin International normalized ratio [INR] |
Atherosclerosis Peripheral Vascular Diseases Vascular Diseases Warfarin Ischemia |
Anticoagulants Therapeutic Uses Hematologic Agents Cardiovascular Diseases Pharmacologic Actions |