Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance - Full Text View

Sponsors and Collaborators:	University Hospital, Basel, Switzerland Bayer
Information provided by:	University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:	NCT00139984

Purpose

The purpose of this study is to determine whether in patients with arterial hypertension, treatment guidance using 24-hour blood pressure measurement results in better blood pressure control compared to treatment guidance using office blood pressure measurement.

Condition	Intervention	Phase
Hypertension	Device: 24 hour blood pressure measurement	Phase IV

MedlinePlus related topics: High Blood Pressure

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Impact of Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance in Medical Outpatients: The Hyper-ABC Study

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:

Change in 24-hour systolic blood pressure from baseline to 1 year

Secondary Outcome Measures:

Change in 24-hour diastolic blood pressure from baseline to 1 year
Primary outcome measure in patients with treated hypertension at baseline

Estimated Enrollment:	170
Study Start Date:	October 2003
Study Completion Date:	May 2007

Detailed Description:

Blood pressure control in arterial hypertension remains poor, despite the availability of effective drug treatment. Therefore, strategies to increase blood pressure control are urgently needed. 24 hour blood pressure is a better predictor of cardiovascular morbidity and mortality than office blood pressure. Furthermore, the lower variability of measurements over time of 24 hour blood pressure could allow better adjustment of antihypertensive therapy. However, there are only scarce data about antihypertensive treatment adjustment using 24 hour blood pressure instead of office blood pressure.

Aim: To test the hypothesis that a 24 hour blood pressure guided therapy is is more effective in reaching blood pressure control when compared to conventional office blood pressure guided therapy.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Uncontrolled hypertension (office BP >139/89mmHg AND 24h BP >129/79mmHg)

Exclusion Criteria:

Severe concomitant illness including heart failure, significant valvular heart disease or malignancy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00139984

Locations

Switzerland
Medical Outpatient Clinic, University Hospital Basel
Basel, Switzerland, 4031
Private Practice
Basel, Switzerland, 4057

Sponsors and Collaborators

University Hospital, Basel, Switzerland

Bayer

Investigators

Principal Investigator:	David Conen, MD	Cardiology, University Hospital Basel
Principal Investigator:	Benedict Martina, MD	Medical Outpatient Clinic, University Hospital Basel

More Information

Study ID Numbers:	EKBB183/03
Study First Received:	August 29, 2005
Last Updated:	August 29, 2007
ClinicalTrials.gov Identifier:	NCT00139984
Health Authority:	Switzerland: Swissmedic

Keywords provided by University Hospital, Basel, Switzerland:

Hypertension
Ambulatory blood pressure monitoring
Blood pressure
Risk assessment

Study placed in the following topic categories:

Vascular Diseases
Hyperkinesis
Hypertension

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009