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| Sponsored by: |
Saint Antoine University Hospital |
|---|---|
| Information provided by: | Saint Antoine University Hospital |
| ClinicalTrials.gov Identifier: | NCT00139958 |
Purpose
Objectives: Evaluate differences for mortality, morbidity and the cardiovascular risk factors between HIV and non-HIV patients with an acute coronary syndromes (ACS) after a 3-years follow up.
| Study Type: | Observational |
| Study Design: | Natural History, Longitudinal, Case Control, Prospective Study |
| Official Title: | Prognosis After Acute Coronary Syndrome in HIV-Infected Patients |
| Estimated Enrollment: | 300 |
| Study Start Date: | November 2003 |
| Estimated Study Completion Date: | April 2009 |
Background: There have been many cases of myocardial infarction reported in HIV-infected young adults treated with HAART. Little is known to date, concerning the outcome and prognostic factors of patients with acute coronary syndrome and HIV-infection.
Methods: Prospective cohort study to compare the evolution and prognosis between HIV and non-HIV patients with an ACS.
Duration of the study: Two years for including patients. Three years of follow-up 100 HIV-patients with ACS and 200 non-HIV patients with ACS will be included in the study. All patients will be included in the study from 30 Intensive Care Unit of Cardiology departments in France.
Results: To compare the incidence of total mortality, cardiovascular mortality (myocardial infarction, sudden death, cardiogenic shock, fatal stroke), morbidity (non fatal myocardial infarction, unstable angina, recurrence of ischemia, cardiac failure, non fatal stroke) and revascularization (percutaneous coronary intervention, coronary artery bypass graft surgery) during a 3-year follow-up between HIV and non-HIV patients with ACS. Univariate and multivariate analysis of predictive factors for cardiovascular events will be done.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| France | |
| Cardiology department | Recruiting |
| Paris, France, 75012 | |
| Contact: Franck Boccara, MD +33149282449 franck.boccara@sat.ap-hop-paris.fr | |
| Principal Investigator: Franck Boccara, MD | |
| Study Chair: | Ariel Cohen, MD, PhD | Saint Antoine University Hospital |
More Information
| Study ID Numbers: | PACS |
| Study First Received: | August 29, 2005 |
| Last Updated: | August 29, 2005 |
| ClinicalTrials.gov Identifier: | NCT00139958 |
| Health Authority: | France: Afssaps - French Health Products Safety Agency |
|
Acute coronary syndrome HIV infection Prognosis Coronary heart disease Revascularization |
|
Arterial Occlusive Diseases Sexually Transmitted Diseases, Viral Heart Diseases Myocardial Ischemia Acquired Immunodeficiency Syndrome Vascular Diseases Arteriosclerosis Ischemia |
Immunologic Deficiency Syndromes Coronary Disease Virus Diseases HIV Infections Acute Coronary Syndrome Sexually Transmitted Diseases Retroviridae Infections Coronary Artery Disease |
|
RNA Virus Infections Pathologic Processes Disease Slow Virus Diseases Immune System Diseases |
Syndrome Lentivirus Infections Cardiovascular Diseases Infection |
