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Sponsors and Collaborators: |
Groupe Hospitalier Pitie-Salpetriere Institut National de la Santé Et de la Recherche Médicale, France |
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Information provided by: | Groupe Hospitalier Pitie-Salpetriere |
ClinicalTrials.gov Identifier: | NCT00139308 |
Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.
Condition | Intervention | Phase |
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Tourette's Syndrome |
Device: high frequency stimulation |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study |
Official Title: | Pilot Study of Internal Globus Pallidus or Median Centre of the Thalamus High Frequency Stimulation for the Treatment of Patients With Severe Tourette's Syndrome |
Ages Eligible for Study: | 18 Years to 55 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
France | |
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere | |
Paris, France, 75013 |
Study Director: | Yves Agid, MD, PhD | CIC-Pitié-Salpêtrière |
Study ID Numbers: | RBM0008 |
Study First Received: | August 30, 2005 |
Last Updated: | August 30, 2005 |
ClinicalTrials.gov Identifier: | NCT00139308 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Tourette's syndrome High frequency stimulation Globus pallidus Thalamus |
Ganglion Cysts Basal Ganglia Diseases Central Nervous System Diseases Tourette Syndrome Tic Disorders Brain Diseases Neurodegenerative Diseases |
Tics Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Movement Disorders Mental Disorders Mental Disorders Diagnosed in Childhood Gilles de la Tourette's syndrome |
Pathologic Processes Disease Syndrome Nervous System Diseases |