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Sponsors and Collaborators: |
Vanderbilt University National Alliance for Research on Schizophrenia and Depression |
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Information provided by: | Vanderbilt University |
ClinicalTrials.gov Identifier: | NCT00288340 |
The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. The investigators will use advanced magnetic resonance imaging (MRI) techniques to measure the degree and distribution of neuronal activity during specific cognitive tasks, alterations in neuronal connectivity, and how these are related to disease symptoms and treatment.
Condition | Intervention |
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Schizophrenia Schizoaffective Disorder Hallucinations |
Device: functional magnetic resonance imaging |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Active Control, Parallel Assignment, Pharmacokinetics/Dynamics Study |
Official Title: | Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging |
Estimated Enrollment: | 60 |
Study Start Date: | January 2006 |
Study Completion Date: | August 2006 |
Primary Completion Date: | August 2006 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1,2: Active Comparator | Device: functional magnetic resonance imaging |
The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. We will use advanced magnetic resonance imaging (MRI) techniques to measure the degree and distribution of neuronal activity during specific cognitive tasks, alterations in neuronal connectivity, and how these are related to disease symptoms and treatment. We will focus on changes in brain structure and function associated with frequent auditory hallucinations, one of the most disabling manifestations of schizophrenia, and with neuroleptic treatment. In order to address these aims, we will study four groups of subjects:
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Investigators will study subjects who:
Normal controls must :
Exclusion Criteria:
Subjects and normal controls will be excluded from participation if there is:
United States, Tennessee | |
Vanderbilt University Medical Center | |
Nashville, Tennessee, United States, 37212 |
Principal Investigator: | Adam Anderson, Ph.D. | Vanderbilt University |
Responsible Party: | Vanderbilt Medical Center ( Adam Anderson, Ph.D. ) |
Study ID Numbers: | 050978, NARSAD |
Study First Received: | February 6, 2006 |
Last Updated: | August 12, 2008 |
ClinicalTrials.gov Identifier: | NCT00288340 |
Health Authority: | United States: Institutional Review Board |
psychotic disorders auditory hallucinations brain structure psychiatric disorder with auditory hallucinations (at least one every 20 minutes) schizophrenia/schizoaffective disorder without auditory hallucinations |
Schizophrenia Signs and Symptoms Mental Disorders Hallucinations Neurologic Manifestations |
Psychotic Disorders Congenital Abnormalities Neurobehavioral Manifestations Schizophrenia and Disorders with Psychotic Features Perceptual Disorders |
Nervous System Diseases |