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Sponsors and Collaborators: |
HP Therapeutics Foundation Huntington Study Group |
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Information provided by: | HP Therapeutics Foundation |
ClinicalTrials.gov Identifier: | NCT00313495 |
The purpose of this study is to collect prospective data from individuals who are part of a Huntington Disease (HD) family, in order to relate phenotypes between individuals and families with each other and genetic factors in order to learn more about HD, develop potential treatments for HD, and to plan for future research studies of experimental drugs aimed at slowing or postponing the onset and progression of HD.
Condition |
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Huntington Disease |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Cooperative Huntington's Observational Research Trial |
Blood, DNA and Urine
Estimated Enrollment: | 5000 |
Study Start Date: | February 2006 |
Estimated Study Completion Date: | December 2010 |
Estimated Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
COHORT (Cooperative Huntington Observational Research Trial) is a coordinated research effort by Huntington Study Group research centers worldwide to prospectively collect data from consenting individuals who are affected by Huntington's disease (HD) and who are part of an HD family. The systematically accrued data from annual prospective assessments will relate clinical characteristics (phenotypes) between families with genetic and environmental factors. The knowledge from these relationships will better inform us about the onset and progression of HD, help identify potential interventions for HD, and aid in planning research studies of experimental treatments aimed at slowing or postponing the onset of HD. The consented collection of biological samples will further provide research material and correlative data for scientists to identify biomarkers that parallel the development and progression of HD. Identification of biomarkers will in turn contribute to our understanding of HD and enhance the efficiency and power of disease-modifying therapeutic trials.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
Exclusion Criteria:
Contact: Huntington Study Group | 800-487-7671 |
Principal Investigator: | Ira Shoulson, MD | University of Rochester/Huntington Study Group |
Responsible Party: | University of Rochester ( Ira Shoulson, MD/Principal Investigator ) |
Study ID Numbers: | COHORT |
Study First Received: | April 10, 2006 |
Last Updated: | April 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00313495 |
Health Authority: | United States: Institutional Review Board |
Huntington disease, observational, family members, biomarker |
Ganglion Cysts Huntington disease Basal Ganglia Diseases Central Nervous System Diseases Brain Diseases Neurodegenerative Diseases Dyskinesias Cognition Disorders Chorea |
Delirium, Dementia, Amnestic, Cognitive Disorders Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Mental Disorders Movement Disorders Dementia Huntington Disease Delirium |
Nervous System Diseases |