Comparative Study of Duration of Respiratory Weaning Between Adaptive Support Ventilation and Succession of Controlled Ventilation Then Spontaneous Ventilation for Patients After Surgery - Full Text View

Sponsored by:	University Hospital, Clermont-Ferrand
Information provided by:	University Hospital, Clermont-Ferrand
ClinicalTrials.gov Identifier:	NCT00313326

Purpose

This is a comparative study of duration of respiratory weaning between adaptive support ventilation and succession of controlled ventilation then spontaneous ventilation for patients after surgery.

Condition	Intervention	Phase
Ventilator Weaning	Procedure: Adaptative Support Ventilation	Phase III

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind (Subject), Active Control, Single Group Assignment
Official Title:	Comparative Study of Duration of Respiratory Weaning Between Adaptive Support Ventilation and Succession of Controlled Ventilation Then Spontaneous Ventilation for Patients After Surgery

Further study details as provided by University Hospital, Clermont-Ferrand:

Primary Outcome Measures:

Duration of weaning [ Time Frame: duration ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

Memorizing of weaning [ Time Frame: memorizing ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	66
Study Start Date:	February 2005
Study Completion Date:	September 2005
Primary Completion Date:	September 2005 (Final data collection date for primary outcome measure)

Intervention Details:

Adaptive Support Ventilation (ASV) is a new protocol of weaning of the tracheal prosthesis after surgery which maintains a preset ventilation by an operator, and this whatever the activity of the patient

Detailed Description:

General anaesthesia is marked by the passage of a stage of controlled ventilation where the patient does not carry out any respiratory work and the stage of spontaneous ventilation, which precedes extubation. Adaptive support ventilation (ASV) is a new protocol of weaning of the tracheal prosthesis after surgery which maintains a preset ventilation by an operator and the activity of the patient. At each breath, a microprocessor allows an optimization of volume and frequency by an adjustment of the inspiratory pressure and frequency. ASV was already validated for fast tracheal extubation after cardiac surgery. Our study proposes to compare the duration of intubation between this mode of weaning and with the traditional way (controlled ventilation then spontaneous ventilation) for faster surgery. The purpose of the study is to check the interest of ASV to limit the duration of intubation compared to the traditional protocol in this kind of intervention.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Surgery < 2 hours
Anesthesia with thiopental, midazolam, sufentanil and suprane

Exclusion Criteria:

Patients ASA III or IV (classification of American Sociéty of Anesthésiologist)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00313326

Locations

France
Clermont-Ferrand University Hospital
Clermont-Ferrand, France, 63000

Sponsors and Collaborators

University Hospital, Clermont-Ferrand

Investigators

Principal Investigator:

Eric Schneider, Doctor

University Hospital, Clermont-Ferrand

More Information

Publications:

Petter AH, Chiolero RL, Cassina T, Chassot PG, Muller XM, Revelly JP. Automatic "respirator/weaning" with adaptive support ventilation: the effect on duration of endotracheal intubation and patient management. Anesth Analg. 2003 Dec;97(6):1743-50.

Sulzer CF, Chiolero R, Chassot PG, Mueller XM, Revelly JP. Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized controlled study. Anesthesiology. 2001 Dec;95(6):1339-45.

Responsible Party:	CHU Clermont-Ferrand ( Dr Eric Schneider )
Study ID Numbers:	CHU63-005
Study First Received:	April 11, 2006
Last Updated:	October 7, 2008
ClinicalTrials.gov Identifier:	NCT00313326
Health Authority:	France: Ministry of Health

Keywords provided by University Hospital, Clermont-Ferrand:

Adaptive Support ventilation
Weaning

ClinicalTrials.gov processed this record on January 16, 2009