INCLUSION:

• Age: 2 years of age and older
• Sex: male or female; female patients with child bearing potential must have a negative serum HCG pregnancy test within 72 hours prior to treatment;

• Diagnostic criteria- Patients must meet all of the following:

  1. Histologically documented neuroendocrine tumor.
  2. Labeled MIBG concentration in the tumor site(s) on diagnostic scan.
  3. good to excellent performance status.
• A patient for whom written voluntary informed consent has been obtained prior to study and participation.
• Patients can have had prior chemotherapy, as long as hematological parameters meet specifications.
• Please refer to Appendix D Drugs and Other Interactions for list of medications patient needs to cease 2 weeks prior to therapy. Patient should check with primary physician after therapy about resuming these medications.
• Patients with treatment refractory or relapsed advanced or disease not amendable to significant response (>25% to available chemotherapy) or metastatic disease not amenable to standard therapy.

EXCLUSION:

• Patients with inadequate hematopoietic bone marrow function: ANC<1000 cells/mm3, or platelets<75k cells/mm3 or hemoglobin<10g/dL.
• Patients with impaired renal function: creatinine>1.5mg/dL.
• Patients with impaired hepatic function: AST or ALT > 3.0 X upper limit of normal or total bilirubin > 2.0 mg/dL.
• Patients with dementia or altered mental status that would prohibit the giving and understanding of informed consent at time of study entry.
• Female patients who are breast-feeding.
• Children less than 2 years of age.
• Patients with previous total body irradiation.