Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Soroka University Medical Center Ben-Gurion University of the Negev |
---|---|
Information provided by: | Soroka University Medical Center |
ClinicalTrials.gov Identifier: | NCT00320892 |
Dying patients are often unable to clear secretions from their large airways, resulting in noisy breathing usually described as "death rattle." While there is no evidence that patients find this condition disturbing, the noises may be disturbing to the patient's visitors and caregivers who may fear that the patient is choking to death.
In Israel none of the pharmaceutical drugs listed in the literature exist. Thus, Atropine drops which have been noted in the literature as being used, though according to our knowledge no evidence of clinical trials using sublingual Atropine were conducted.
The study is designed as a randomly controlled, double blind crossover trial. The patient will serve as control for himself, as crossover between placebo and drug (randomly chosen) will take place. The administrator of the drug will be blinded to the medication, each time randomly beginning with a different drug (placebo or Atropine).
We will evaluate Atropine Sulphate 1% ophthalmic drops effect on 33 patients using a noise score scale of 0-3. Noise scores will be taken at the start; 30 min after drug/placebo administration and every hour thereafter. After 4-hours crossover will take place and evaluation will follow the same protocol.
Condition | Intervention |
---|---|
Noise Death |
Drug: Atropine Sulphate 1% ophthalmic drops |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
-
Contact: Pesach Shvartzman, MD | 972-8-6477429 | spesah@bgu.ac.il |
Contact: Valentina Semionov, MD | 972-8-6477436 | : valsem2002@yahoo.com |
Israel | |
Ben-Gurion University of the Negev, Sial Research Center for Family Medicine and Primary Care | Recruiting |
Beer-Sheva, Israel, 653 | |
Contact: Pesach Shvartzman, MD 972-8-6477429 | |
Principal Investigator: Valentina Semionov, MD |
Study Chair: | Pesach Shvartzman | Ben-Gurion University of the Negev |
Study ID Numbers: | SOR416506CTIL |
Study First Received: | May 1, 2006 |
Last Updated: | March 26, 2008 |
ClinicalTrials.gov Identifier: | NCT00320892 |
Health Authority: | Israel: Ministry of Health |
Death Rattle Noise level Primary Care |
Death Atropine |
Parasympatholytics Respiratory System Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cholinergic Antagonists Physiological Effects of Drugs Anti-Asthmatic Agents Cardiovascular Agents Cholinergic Agents Pharmacologic Actions |
Muscarinic Antagonists Adjuvants, Anesthesia Mydriatics Pathologic Processes Autonomic Agents Therapeutic Uses Anti-Arrhythmia Agents Peripheral Nervous System Agents Central Nervous System Agents Bronchodilator Agents |