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Sponsors and Collaborators: |
University Hospital, Bonn German Federal Ministry of Education and Research |
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Information provided by: | University Hospital, Bonn |
ClinicalTrials.gov Identifier: | NCT00279604 |
INCA (Intervention and Neuropsychology of Cannabis Abuse) is a study combining two research goals. One is to study efficacy of a short intervention the ‘Problem Profile Intervention’, which utilizes individual feedback from a ‘substance problem check-up’. Subjects will randomly receive the ‘Problem Profile Intervention’ or the WHO Brief Intervention, a brief intervention, which has been shown to be efficacious. Currently efficiency studies are under way. The WHO Brief Intervention has been translated into German by our group. In contrast to most other cannabis intervention studies the current study is focussed on cannabis abusers not so much cannabis-dependent subjects. A total of 160 subjects are to be recruited. Half of them will randomly receive either the Problem Profile Intervention or the WHO Brief Intervention (active control). A total of 25% of subjects from each group will be placed on a 3 months waiting list before receiving the intervention (inactive control). Intervention outcome will be assessed three months, six month and 12 months after the intervention. We hypothesize cannabis use to be reduced by 25% by the 'Problem Profile Intervention'. The second aim of the study is to study mechanism of substance abuse. Initial results from own studies and data from other groups point to executive cognitive functions as a subtle but important factor that can be compromised in cannabis users (Verdejo-Garcia et al., 2004; Garavan and Stout, 2005). Using an fMRI-study, we intend to examine a subgroup of our subjects on a specific aspect of executive functioning that has recently received major interest in drug research: Decision-making capability, or risk-taking behaviour, respectively (e.g. Ernst and Paulus, 2005).
Condition | Intervention |
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Marijuana Abuse |
Behavioral: 'Problem Profile Intervention' vs. WHO-Brief Intervention |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | Targeted Interventions in Cannabis Abuse: Focus on Decision Making (INCA) |
Ages Eligible for Study: | 16 Years to 36 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
exclusion criteria for fMRI-part:
Contact: Christian G Schuetz, MD MPH | +49 228 287 9664 | christian.schütz@ukb.uni-bonn.de |
Germany, NRW | |
Friedrich-Wilhelms-University, Department of Psychiatry | Recruiting |
Bonn, NRW, Germany, 53105 | |
Contact: Christian G Schütz, MD MPH +49 228 2879664 christian.schütz@ukb.uni-bonn.de | |
Principal Investigator: Christian G Schütz, MD MPH | |
University of Essen, Department of Psychiatry and Psychotherapy | Recruiting |
Essen, NRW, Germany, 45147 | |
Contact: Norbert Scherbaum, MD +49 201 7227 180 norbert.scherbaum@uni-essen.de | |
Principal Investigator: Norbert Scherbaum, MD |
Principal Investigator: | Christian G Schuetz, MD MPH | University of Bonn, Department of Psychiatry |
Study ID Numbers: | 01EB0432 |
Study First Received: | January 18, 2006 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00279604 |
Health Authority: | Germany: Federal Institute for Drugs and Medical Devices |
Mental Disorders Substance-Related Disorders Disorders of Environmental Origin Marijuana Abuse |