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Sponsored by: |
Katholieke Universiteit Leuven |
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Information provided by: | Katholieke Universiteit Leuven |
ClinicalTrials.gov Identifier: | NCT00593671 |
In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS.
In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.
Condition | Intervention |
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In Vitro Fertilization |
Procedure: Preimplantation genetic screening after embryo biopsy |
Study Type: | Interventional |
Study Design: | Basic Science, Randomized, Open Label, Parallel Assignment |
Official Title: | Preimplantation Genetic Screening for Aneuploidy in Embryos After in Vitro Fertilization in Women Over 35: a Prospective Controlled Randomized Study. |
Enrollment: | 100 |
Study Start Date: | June 2002 |
Study Completion Date: | January 2007 |
Primary Completion Date: | January 2007 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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PGS group: Active Comparator |
Procedure: Preimplantation genetic screening after embryo biopsy
Preimplantation genetic screening after embryo biopsy
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control group: No Intervention |
Ages Eligible for Study: | 35 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Leuven University Fertility Center ( Thomas D'Hooghe ) |
Study ID Numbers: | sdbroc0 |
Study First Received: | January 4, 2008 |
Last Updated: | January 14, 2008 |
ClinicalTrials.gov Identifier: | NCT00593671 |
Health Authority: | Belgium: The Federal Public Service (FPS) Health, Food Chain Safety and Environment |
aneuploidies in 7 chromosomes increased with advanced maternal age |
Aneuploidy |