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Research Highlights
Study yields mixed findings on popular arthritis supplements
February 23, 2006
A nationwide clinical trial led by a VA investigator and involving nearly 1,600 patients with osteoarthritis of the knee found little benefit overall for the widely used nutritional supplements glucosamine and chondroitin sulfate. The findings did suggest, however that the supplements may help those with more severe pain. The study, led by Dr. Daniel Clegg of the Salt Lake City VA and the University of Utah and funded by the National Institutes of Health, was the most rigorous trial to date of the supplements, which are taken either alone or in combination by millions of arthritis sufferers around the world.
Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3rd, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, Wolfe F, Molitor JA, Yocum DE, Schnitzer TJ, Furst DE, Sawitzke AD, Shi H, Brandt KD, Moskowitz RW, Williams HJ. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.
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