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Sponsored by: |
AstraZeneca |
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Information provided by: | AstraZeneca |
ClinicalTrials.gov Identifier: | NCT00625274 |
This study looks at controlling intragastric pH following administration of esomeprazole 40 mg, lansoprazole 30 mg and pantoprazole 40 mg taken orally, once daily in patients taking either non-selective or cyclooxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs (NSAIDs).
Condition | Intervention | Phase |
---|---|---|
Heartburn Upper Abdominal Pain Nausea Acid Regurgitation |
Drug: Esomeprazole Drug: Lansoprazole Drug: Pantoprazole |
Phase IV |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Crossover Assignment, Pharmacodynamics Study |
Estimated Enrollment: | 100 |
Study Start Date: | June 2004 |
Study Completion Date: | November 2004 |
Primary Completion Date: | November 2004 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
1: Experimental
Oral
|
Drug: Esomeprazole
40mg Oral
|
2: Experimental
Oral
|
Drug: Lansoprazole
30mg Oral
|
3: Experimental
Oral
|
Drug: Pantoprazole
40mg Oral
|
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | AstraZeneca ( Tore Lind, MD - Nexium Medical Science Director ) |
Study ID Numbers: | D9612L00063 |
Study First Received: | February 20, 2008 |
Last Updated: | February 27, 2008 |
ClinicalTrials.gov Identifier: | NCT00625274 |
Health Authority: | United States: Food and Drug Administration |
Nexium esomeprazole lansoprazole pantoprazole Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) |
Signs and Symptoms Pyrosis Signs and Symptoms, Digestive Abdominal Pain Pantoprazole |
Heartburn Omeprazole Nausea Pain Lansoprazole |
Anti-Infective Agents Molecular Mechanisms of Pharmacological Action Therapeutic Uses Anti-Ulcer Agents |
Gastrointestinal Agents Enzyme Inhibitors Pharmacologic Actions |