Dichloroacetate Kinetics, Metabolism and Toxicology

This study has been completed.

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00015015

Purpose

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as an investigational drug for treating various diseases of adults and children, at doses far greater than those to which humans are normally exposed in the environment. Our research involves how DCA is metabolized by healthy adults and by children with a fatal genetic disease, congenital lactic acidosis (CLA) who are treated with DCA.

Condition	Intervention
Lactic Acidosis	Drug: Dichloroacetate

Drug Information available for: Dichloroacetate Sodium dichloroacetate

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment:	100
Study Start Date:	December 1994
Estimated Study Completion Date:	October 2002

Eligibility

Ages Eligible for Study:	3 Months to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Children with congenital lactic acidosis Healthy adult volunteers

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00015015

Locations

United States, Florida
Univ. of Florida
Gainesville, Florida, United States, 32610

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

More Information

Study ID Numbers:	7355-CP-001
Study First Received:	April 17, 2001
Last Updated:	September 1, 2006
ClinicalTrials.gov Identifier:	NCT00015015
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

Dichloroacetate
Chlorinated hydrocarbons
Genetic disease
Toxicology
Biotransformation

Study placed in the following topic categories:

Metabolic Diseases
Acidosis, Lactic
Metabolic disorder
Acidosis

Additional relevant MeSH terms:

Acid-Base Imbalance

ClinicalTrials.gov processed this record on January 16, 2009