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Osteoarthritis: Weakness From Inflammation
This study is currently recruiting participants.
Verified by National Institute on Aging (NIA), August 2008
Sponsored by: National Institute on Aging (NIA)
Information provided by: National Institute on Aging (NIA)
ClinicalTrials.gov Identifier: NCT00104312
  Purpose

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.


Condition
Osteoarthritis

MedlinePlus related topics: Osteoarthritis
U.S. FDA Resources
Study Type: Observational
Study Design: Cohort, Cross-Sectional
Official Title: Weakness From Inflammation: A Basis of Disability From Knee Osteoarthritis

Further study details as provided by National Institute on Aging (NIA):

Biospecimen Retention:   Samples Without DNA

Biospecimen Description:

Synovial fluid and tissue blood serum muscle biopsy


Estimated Enrollment: 88
Study Start Date: April 2001
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Participants with symptomatic knee osteoarthritis
2
Participants without symptomatic knee osteoarthritis, age-matched as controls

Detailed Description:

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Community - Men and women

Criteria

Inclusion Criteria:

  • 50 years of age or older
  • Normal body weight (a Body Mass Index (BMI) of 30 or less)
  • Osteoarthritis of the knee (prior to knee surgery)
  • Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria:

  • History of a stroke
  • History of muscle weakness or paralysis
  • History of Rheumatoid Arthritis or
  • Inflammatory Joint Disease
  • History of a Bleeding Disorder
  • History of Gout
  • Diabetes for which you take insulin
  • Polymyalgia rheumatica (total body muscle aching/stiffness)
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00104312

Contacts
Contact: NIA Recruiter 410-350-3941 or 800-225-2572 ext 3941 NIAStudiesRecruitmetmn@mial.nih.gov

Locations
United States, Maryland
Harbor Hospital Recruiting
Baltimore, Maryland, United States, 21225
Contact: NIA Recruiter     410-350-3941     NIASTudiesRecruitment@mail.nih.gov    
Principal Investigator: Shari Ling, MD            
Sponsors and Collaborators
Investigators
Principal Investigator: Shari Ling, MD NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics
  More Information

Publications:
Responsible Party: National Institute on Aging ( Shari Ling, MD, Principal Investigator )
Study ID Numbers: AG0016
Study First Received: February 24, 2005
Last Updated: August 22, 2008
ClinicalTrials.gov Identifier: NCT00104312  
Health Authority: United States: Federal Government

Keywords provided by National Institute on Aging (NIA):
Knee Osteoarthritis
Muscle
Cytokine
Mobility
Function

Study placed in the following topic categories:
Osteoarthritis, Knee
Musculoskeletal Diseases
Asthenia
Osteoarthritis
Joint Diseases
Arthritis
Rheumatic Diseases
Inflammation

Additional relevant MeSH terms:
Pathologic Processes

ClinicalTrials.gov processed this record on January 30, 2009