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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00018603 |
This is a double-blind, placebo-controlled, randomized study lasting 8 weeks. Purpose of the study is two-fold: first, to use a pharmacological agent to treat symptoms of PTSD, and second, to explore neurobiological mechanisms of action of guanfacine.
Condition | Intervention | Phase |
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Post-Traumatic Stress Disorder |
Drug: guanfacine |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Guanfacine for the Treatment of PTSD |
Study Start Date: | November 1999 |
Estimated Study Completion Date: | October 2002 |
Subject population is comprised of 100 persons with PTSD. 50 patients will receive guanfacine and 50 patients will receive a placebo. Guanfacine is prescribed at 1 mg/day and may be increased to 2 mg/day. Samples of plasma MHPG will be collected weekly. Clinical ratings of PTSD anxiety and depression, as well as vital signs, will be assessed weekly. Repeated measures analysis of variance will assess significance of main effect of drug, time, and drug by time.
Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Study ID Numbers: | MHBS-047-99F |
Study First Received: | July 3, 2001 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00018603 |
Health Authority: | United States: Federal Government |
PTSD |
Anxiety Disorders Guanfacine Mental Disorders |
Stress Disorders, Post-Traumatic Stress Stress Disorders, Traumatic |
Neurotransmitter Agents Adrenergic alpha-Agonists Pathologic Processes Disease Molecular Mechanisms of Pharmacological Action Adrenergic Agents |
Therapeutic Uses Physiological Effects of Drugs Cardiovascular Agents Antihypertensive Agents Adrenergic Agonists Pharmacologic Actions |