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Sponsored by: |
Odense University Hospital |
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Information provided by: | Odense University Hospital |
ClinicalTrials.gov Identifier: | NCT00143013 |
Type 2 diabetes is a disorder of the metabolic system that greatly affects individual health and imposes significant cost for society on health care. It is necessary to initiate research with emphasis on improvement on quality of life and reduce the serious complications as a result of type 2 diabetes.
In type 2 diabetes insulin resistance and impairment of insulin secretion by beta-cells are the major pathophysiological defects and characterized by raised plasma glucose levels. Today, little is known about gene regulation and biochemical pathways involved in the disease.
Bioinformatics and gene expression microarrays (GEM) will be applied to gain insight into the molecular pathophysiology of type 2 diabetes. The simultaneous monitoring of thousands of genes in parallel can identify novel genes and entire biochemical pathways that are dysregulated at the transcriptional level. Affymetrix Inc. chips or spotted arrays will be applied as DNA microarray tools. Bioinformatic software programs and databases will be employed as data mining tools in order to perform statistical analysis, cluster analysis and biochemical pathway analysis.
Biopsies from skeletal muscle and adipose tissue from both diabetics and nondiabetics will be applied. Changes in genes and biochemical pathways between diabetics and nondiabetics and functional relationships between adipose tissue and skeletal muscle will be investigated.
Grouping of subtypes in type 2 diabetes will be performed and a classification system will be constructed. Building a classifier may provide better and more precise diagnosis of type 2 diabetes.
Major advances in health science of type 2 diabetes thus seems to be promising and paving the way for individual treatment based on a more precise diagnosis.
Condition |
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Type 2 Diabetes |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Gene Expression Profiling by DNA Chips and Subsequent Bioinformatic Analysis for Identification of Genes and Biochemical Pathways Associated With Type 2 Diabetes |
Ages Eligible for Study: | 30 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Of diabetic subjects:
Of nondiabetic subjects:
Exclusion Criteria:
Of diabetic subjects:
Of nondiabetic subjects:
Contact: Vibe Skov, PhD | vibe.skov@ouh.regionsyddanmark.dk |
Denmark, Funen | |
Department of Clinical Biochemistry and Genetics, KKA | Recruiting |
Odense C, Funen, Denmark, 5000 | |
Contact: Vibe Skov, MSc +45 6541 2837 vibe.skov@ouh.fyns-amt.dk |
Principal Investigator: | Vibe Skov, MSc | Odense University Hospital |
Study ID Numbers: | 002 |
Study First Received: | September 1, 2005 |
Last Updated: | June 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00143013 |
Health Authority: | Denmark: National Board of Health |
type 2 diabetes microarray skeletal muscle bioinformatics |
Metabolic Diseases Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases |
Endocrinopathy Metabolic disorder Glucose Metabolism Disorders |