• Visually significant age-related macular degeneration (AMD) [ Designated as safety issue: No ]
  
• Visually significant cataract [ Designated as safety issue: No ]
  

• Advanced AMD (evidence of geographic atrophy or exudative disease) [ Designated as safety issue: No ]
  
• Total AMD (with or without vision loss) [ Designated as safety issue: No ]
  
• Surgical removal of an incident cataract or subtype [ Designated as safety issue: No ]
  

OBJECTIVES:

Primary

• To test whether vitamin E and/or selenium reduces the risk of visually significant age-related macular degeneration (AMD) in older men enrolled on SELECT clinical trial SWOG-S0000.
• To test whether vitamin E and/or selenium reduces the risk of cataract in these participants.

Secondary

• To test whether vitamin E and/or selenium reduces the risk of advanced AMD in these participants.
• To test whether vitamin E and/or selenium reduces the risk of cataract surgery and subtypes in these participants.

OUTLINE: This is a multicenter study.

Data from medical records obtained from the participant's ophthalmologist or optometrist are reviewed. Information from these records is then used to confirm baseline reports of age-related macular degeneration (AMD) as well as 6-month and annual reports of new diagnoses of AMD and cataract (or cataract surgery) made since the start of this study. Detailed questionnaires are also obtained from the participant's ophthalmologist or optometrist to provide information about the reported AMD or cataract diagnosis (e.g., date of initial diagnosis; best-corrected visual acuity at the time of diagnosis; date when visual acuity was first noted to be 20/30 or worse [if different from the date of initial diagnosis]; pathological findings observed when AMD was first diagnosed [e.g., drusen, retinal pigment epithelial hypo/hyperpigmentation, geographic atrophy, retinal pigment epithelial detachment, subretinal neovascular membrane, or disciform scar]; pathological findings observed when visual acuity was first noted to be 20/30 or worse; date when exudative [wet] AMD was first noted; presence of other ocular abnormalities that could explain or contribute to visual loss; whether AMD or cataract, by itself, are significant enough to cause vision to be reduced to 20/30 or worse; whether laser treatment or photodynamic therapy was performed for AMD; date of cataract extraction; etiology of cataract [e.g., age-related, traumatic, congenital, inflammatory, or surgery- or steroid-induced]; and cataract type [e.g., nuclear, cortical, posterior subcapsular, or other]).