Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy - Full Text View

Sponsors and Collaborators:	Kuopio University Hospital University of Kuopio
Information provided by:	Kuopio University Hospital
ClinicalTrials.gov Identifier:	NCT00594711

Purpose

Outcome of psychodynamic psychotherapy measured by [123I] nor-B-CIT SPET imaging

Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.

The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.

Condition
Depression

MedlinePlus related topics: Depression

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective

Further study details as provided by Kuopio University Hospital:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

DNA, creatine, B-vitamin,BP from blood samples.

Enrollment:	26
Study Start Date:	January 2000
Estimated Study Completion Date:	January 2010

Groups/Cohorts
1 Case-group
2 Control-group

Detailed Description:

N=26

Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. [123I] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.

Eligibility

Ages Eligible for Study:	18 Years to 55 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patiens of clinic

Criteria

Inclusion Criteria:

depression

Exclusion Criteria:

antidepressive medication

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00594711

Sponsors and Collaborators

Kuopio University Hospital

University of Kuopio

Investigators

Principal Investigator:	Jari Tiihonen, Ph.D	Kuopio University Hospital
Study Director:	Johannes Lehtonen, Ph.D	Kuopio University Hospital
Study Chair:	Saarinen Pirjo, Ph.D	Kuopio University Hospital
Study Chair:	Lehto Soili, MD	Kuopio University Hospital
Study Chair:	Minna Valkonen-Korhonen, Ph.D	Kuopio University
Study Chair:	Pasi Ahola, MD	Kuopio University
Study Chair:	Mikko Joensuu, MD	Kuopio University Hospital
Study Chair:	Tommi Tolmunen, Ph.D.	Kuopio University Hospital

More Information

Responsible Party:	Niuvanniemi Hospital ( Jari Tiihonen/ Professor )
Study ID Numbers:	KUH5703410, 118/9/00
Study First Received:	January 7, 2008
Last Updated:	January 15, 2008
ClinicalTrials.gov Identifier:	NCT00594711
Health Authority:	Finland: Ethics Committee

Keywords provided by Kuopio University Hospital:

Psychotherapy
depression

Study placed in the following topic categories:

Depression
Mental Disorders
Mood Disorders
Depressive Disorder
Behavioral Symptoms

ClinicalTrials.gov processed this record on January 16, 2009