Growth Hormone and Heart Failure - Full Text View

Sponsored by:	Assistance Publique - Hôpitaux de Paris
Information provided by:	Assistance Publique - Hôpitaux de Paris
ClinicalTrials.gov Identifier:	NCT00190359

Purpose

Heart failure induces modification in several neurohormonal systems. The aim of this study is to determine if the growth hormone/IGF1 axis is modified in heart failure patients compared to healthy volunteers.

Condition
Heart Failure, Congestive

MedlinePlus related topics: Heart Failure

Drug Information available for: Insulin-like growth factor I Mecasermin rinfabate Somatotropin Somatropin

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Case Control, Retrospective/Prospective Study
Official Title:	Modifications of the Growth Hormone/IGF1 Axis in Heart Failure Patients

Further study details as provided by Assistance Publique - Hôpitaux de Paris:

Estimated Enrollment:	180
Study Start Date:	September 2000
Estimated Study Completion Date:	February 2003

Detailed Description:

One hundred and sixty three heart failure patients were evaluated by clinical examination, echocardiography, exercise test and measurement of blood BNP. Growth hormone and IGF-1 plasma levels were determined in each patient. The same biological measurements were performed in a group of 148 healthy controls. Comparisons were performed between groups for Growth hormone plasma level, IGF-1 plasma level and Growth hormone/IGF-1 index. A correlation between the severity of heart failure and the different biological parameters was searched.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Heart failure patients in stable condition

Exclusion Criteria:

cancer
pituitary disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00190359

Sponsors and Collaborators

Assistance Publique - Hôpitaux de Paris

Investigators

Principal Investigator:

Patrick Maison, MD, PhD

APHP

More Information

Study ID Numbers:	CRC00007
Study First Received:	September 14, 2005
Last Updated:	September 14, 2005
ClinicalTrials.gov Identifier:	NCT00190359
Health Authority:	France: Ministry of Health

Keywords provided by Assistance Publique - Hôpitaux de Paris:

heart failure
hormones
growth substances

Study placed in the following topic categories:

Heart Failure
Heart Diseases

Additional relevant MeSH terms:

Cardiovascular Diseases

ClinicalTrials.gov processed this record on January 16, 2009